Biomaterials elicit pyroptosis enhancing cancer immunotherapy

MJ Zhang, YY Wang, LL Han, XY Liu… - Advanced Functional …, 2024 - Wiley Online Library
Cancer immunotherapy has the potential to revolutionize the treatment of malignant tumors,
but its effectiveness is limited by the low immune response rate and immune‐related …

Roles of oxidative stress in synaptic dysfunction and neuronal cell death in Alzheimer's disease

G Plascencia-Villa, G Perry - Antioxidants, 2023 - mdpi.com
Alzheimer's disease (AD) is a brain disorder that progressively undermines memory and
thinking skills by affecting the hippocampus and entorhinal cortex. The main …

Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis

J Tschuck, L Theilacker, I Rothenaigner… - Nature …, 2023 - nature.com
Ferroptosis is a regulated cell death modality that occurs upon iron-dependent lipid
peroxidation. Recent research has identified many regulators that induce or inhibit …

The roles of ferroptosis in cancer: tumor suppression, tumor microenvironment, and therapeutic interventions

G Lei, L Zhuang, B Gan - Cancer cell, 2024 - cell.com
In cancer treatment, the recurrent challenge of inducing apoptosis through conventional
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …

Targeting immunogenic cell stress and death for cancer therapy

L Galluzzi, E Guilbaud, D Schmidt, G Kroemer… - Nature Reviews Drug …, 2024 - nature.com
Immunogenic cell death (ICD), which results from insufficient cellular adaptation to specific
stressors, occupies a central position in the development of novel anticancer treatments …

[HTML][HTML] Molecular landmarks of tumor disulfidptosis across cancer types to promote disulfidptosis-target therapy

D Zhao, Y Meng, Y Dian, Q Zhou, Y Sun, J Le, F Zeng… - Redox Biology, 2023 - Elsevier
The mystery about the mechanistic basis of disulfidptosis has recently been unraveled and
shows promise as an effective treatment modality for triggering cancer cell death. However …

Cuproptosis and cuproptosis-related genes: Emerging potential therapeutic targets in breast cancer

X Liu, B Luo, X Wu, Z Tang - Biochimica et Biophysica Acta (BBA)-Reviews …, 2023 - Elsevier
Breast cancer is one of the most common malignant tumors in women worldwide, and thus, it
is important to enhance its treatment efficacy [1]. Copper has emerged as a critical trace …

Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond

C Mao, M Wang, L Zhuang, B Gan - Protein & cell, 2024 - academic.oup.com
Cell death resistance represents a hallmark of cancer. Recent studies have identified
metabolic cell death as unique forms of regulated cell death resulting from an imbalance in …

Regulated necrosis role in inflammation and repair in acute kidney injury

J Guerrero-Mauvecin, N Villar-Gómez… - Frontiers in …, 2023 - frontiersin.org
Acute kidney injury (AKI) frequently occurs in patients with chronic kidney disease (CKD)
and in turn, may cause or accelerate CKD. Therapeutic options in AKI are limited and mostly …

SBFI26 induces triple‐negative breast cancer cells ferroptosis via lipid peroxidation

G He, Y Zhang, Y Feng, T Chen, M Liu… - Journal of Cellular …, 2024 - Wiley Online Library
SBFI26, an inhibitor of FABP5, has been shown to suppress the proliferation and metastasis
of tumour cells. However, the underlying mechanism by which SBFI26 induces ferroptosis in …