Recent evidence has suggested that the carotid bodies might act as immunological sensors,
detecting pro-inflammatory mediators and signalling to the central nervous system, which, in …

It has been suggested that inflammation is important in the aetiology of hypertension and
that this may be most relevant among obese persons. To study this, we examined the …

Initially thought to only provide mechanical support for the underlying blood vessels,
perivascular adipose tissue (PVAT) has now emerged as a regulator of vascular function. A …

FLT3L (Fms-like tyrosine kinase 3 ligand) stimulates the development of classical dendritic
cells (DCs). Here we tested the hypothesis that classical DCs drive blood pressure elevation …

Systemic hypertension, preeclampsia, and pulmonary arterial hypertension (PAH) are
diseases of high blood pressure in the systemic or pulmonary circulation. Beyond the well …

Aims Hypertension is associated with increased levels of circulating cytokines and recent
studies have shown that innate immunity contributes to hypertension. The mechanisms …

Patients with obstructive sleep apnoea–hypopnoea syndrome (OSAHS) have elevated
circulating levels of tumour necrosis factor (TNF)-α. The hypothesis in this study was that …

Neural pathways regulate immunity and inflammation via the inflammatory reflex and
specific molecular targets can be modulated by stimulating neurons …

Abstract The world Health Organization defines health as complete well-being in terms of
physical, mental and social, and not merely the absence of disease. To attain this, individual …

Until now, renin–angiotensin system (RAS) hyperactivity was largely thought to result from
angiotensin II (Ang II)-dependent stimulation of the Ang II type 1 receptor (AT1R). Here we …