As newer, molecularly targeted, anticancer drugs are entering clinical practice, a wide array
of previously unrecognised and ill defined side effects of these drugs are increasingly …

Arterial stiffness plays a key role in the pathophysiology of the cardiovascular system. Some
indices of arterial stiffness (pulse wave velocity, augmentation index, characteristics of …

First-line chemotherapy fails in more than 20% of patients with epithelial ovarian cancer and
about 40–50% of women who respond to initial treatment relapse within 2 years. In the …

Oxidative stress and endothelial dysfunction have been associated with essential
hypertension (EH) mechanisms. The purpose of this study was to evaluate the effect of …

What is already known about this subject• The variability in drug metabolism has been
recognized as an important factor in the occurrence of adverse effects or lack of therapeutic …

A simple, sensitive and rapid liquid chromatographic/electrospray ionization tandem mass
spectrometric method was developed and validated for the quantitation of nebivolol in …

Nebivolol is a β1-adrenergic blocker that also elicits renal vasodilation and increases the
glomerular filtration rate (GFR). However, its direct actions on the renal microvasculature …

Nebivolol is a third-generation β-adrenoceptor antagonist. It differs from other β-
adrenoceptor antagonists as it combines highly selective β 1-adrenoceptor antagonist …

Mutations in the endothelial nitric oxide synthase (eNOS) gene may be associated with
abnormal nitric oxide (NO) production and cardiovascular diseases. In this study, we …

Nebivolol is a third generation β-blocker. It is highly selective for the β1-adrenoceptor, and
has additional nitric oxide-mediated vasodilating and antioxidant properties, along with a …