The no-reflow phenomenon refers to the observation that when an organ is made ischemic
by occlusion of a large artery supplying it, restoration of patency in that artery does not …

Efficient insulin secretion requires a well-functioning pancreatic islet microvasculature. The
dense network of islet capillaries includes the islet pericyte, a cell that has barely been …

The heterocellular nature of the heart has been receiving increasing attention in recent
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …

Neurodegenerative and cerebrovascular diseases cause considerable human suffering,
and therapy options for these two disease categories are limited or non‐existing. It is an …

Ischemic heart disease is the greatest health burden and most frequent cause of death
worldwide. Myocardial ischemia/reperfusion is the pathophysiological substrate of ischemic …

Pericytes are branched cells located in the wall of capillary blood vessels that are found
throughout the body, embedded within the microvascular basement membrane and …

BACKGROUND: Pericytes have been implicated in tissue repair, remodeling, and fibrosis.
Although the mammalian heart contains abundant pericytes, their fate and involvement in …

Acute obstruction of a coronary artery causes myocardial ischaemia and if prolonged, may
result in an ST-segment elevation myocardial infarction (STEMI). First-line treatment involves …

Retinal ganglion cells, the neurons that die in glaucoma, are endowed with a high
metabolism requiring optimal provision of oxygen and nutrients to sustain their activity. The …

The prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) quickly
reached pandemic proportions, and knowledge about this virus and coronavirus disease …