August Krogh's theory of muscle microvascular control and oxygen delivery: a paradigm shift based on new data
August Krogh twice won the prestigious international Steegen Prize, for nitrogen metabolism
(1906) and overturning the concept of active transport of gases across the pulmonary …
(1906) and overturning the concept of active transport of gases across the pulmonary …
[HTML][HTML] Retinal ischemia induces α-SMA-mediated capillary pericyte contraction coincident with perivascular glycogen depletion
L Alarcon-Martinez, S Yilmaz-Ozcan, M Yemisci… - Acta neuropathologica …, 2019 - Springer
Increasing evidence indicates that pericytes are vulnerable cells, playing pathophysiological
roles in various neurodegenerative processes. Microvascular pericytes contract during …
roles in various neurodegenerative processes. Microvascular pericytes contract during …
SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction
Abstract The SARS-CoV-2 receptor, ACE2, is found on pericytes, contractile cells
enwrapping capillaries that regulate brain, heart and kidney blood flow. ACE2 converts …
enwrapping capillaries that regulate brain, heart and kidney blood flow. ACE2 converts …
Pericyte-mediated constriction of renal capillaries evokes no-reflow and kidney injury following ischaemia
F Freitas, D Attwell - Elife, 2022 - elifesciences.org
Acute kidney injury is common, with~ 13 million cases and 1.7 million deaths/year
worldwide. A major cause is renal ischaemia, typically following cardiac surgery, renal …
worldwide. A major cause is renal ischaemia, typically following cardiac surgery, renal …
Validation of specific and reliable genetic tools to identify, label, and target cardiac pericytes in mice
Background In the myocardium, pericytes are often confused with other interstitial cell types,
such as fibroblasts. The lack of well‐characterized and specific tools for identification …
such as fibroblasts. The lack of well‐characterized and specific tools for identification …
[HTML][HTML] Emerging role of pericytes and their secretome in the heart
H Su, AC Cantrell, H Zeng, SH Zhu, JX Chen - Cells, 2021 - mdpi.com
Pericytes, as mural cells covering microvascular capillaries, play an essential role in
vascular remodeling and maintaining vascular functions and blood flow. Pericytes are …
vascular remodeling and maintaining vascular functions and blood flow. Pericytes are …
[HTML][HTML] Pathological roles of oxidative stress in cardiac microvascular injury
J Hou, Y Yuan, P Chen, K Lu, Z Tang, Q Liu… - Current Problems in …, 2023 - Elsevier
Cardiac microvascular injury can be a fundamental pathological process that causes high
incidence cardiovascular diseases such heart failure, diabetic cardiomyopathy, and …
incidence cardiovascular diseases such heart failure, diabetic cardiomyopathy, and …
The pericyte microenvironment during vascular development
Vascular pericytes provide critical contributions to the formation and integrity of the blood
vessel wall within the microcirculation. Pericytes maintain vascular stability and homeostasis …
vessel wall within the microcirculation. Pericytes maintain vascular stability and homeostasis …
Repair of the infarcted heart: cellular effectors, molecular mechanisms and therapeutic opportunities
I Hilgendorf, S Frantz, NG Frangogiannis - Circulation Research, 2024 - Am Heart Assoc
The adult mammalian heart has limited endogenous regenerative capacity and heals
through the activation of inflammatory and fibrogenic cascades that ultimately result in the …
through the activation of inflammatory and fibrogenic cascades that ultimately result in the …
Biology and function of pericytes in the vascular microcirculation
Y Wu, J Fu, Y Huang, R Duan, W Zhang… - Animal Models and …, 2023 - Wiley Online Library
Pericytes are the main cellular components of tiny arteries and capillaries. Studies have
found that pericytes can undergo morphological contraction or relaxation under stimulation …
found that pericytes can undergo morphological contraction or relaxation under stimulation …