August Krogh's theory of muscle microvascular control and oxygen delivery: a paradigm shift based on new data

DC Poole, RN Pittman, TI Musch… - The Journal of …, 2020 - Wiley Online Library
August Krogh twice won the prestigious international Steegen Prize, for nitrogen metabolism
(1906) and overturning the concept of active transport of gases across the pulmonary …

[HTML][HTML] Retinal ischemia induces α-SMA-mediated capillary pericyte contraction coincident with perivascular glycogen depletion

L Alarcon-Martinez, S Yilmaz-Ozcan, M Yemisci… - Acta neuropathologica …, 2019 - Springer
Increasing evidence indicates that pericytes are vulnerable cells, playing pathophysiological
roles in various neurodegenerative processes. Microvascular pericytes contract during …

SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction

C Hirunpattarasilp, G James, J Kwanthongdee… - Brain, 2023 - academic.oup.com
Abstract The SARS-CoV-2 receptor, ACE2, is found on pericytes, contractile cells
enwrapping capillaries that regulate brain, heart and kidney blood flow. ACE2 converts …

Pericyte-mediated constriction of renal capillaries evokes no-reflow and kidney injury following ischaemia

F Freitas, D Attwell - Elife, 2022 - elifesciences.org
Acute kidney injury is common, with~ 13 million cases and 1.7 million deaths/year
worldwide. A major cause is renal ischaemia, typically following cardiac surgery, renal …

Validation of specific and reliable genetic tools to identify, label, and target cardiac pericytes in mice

L Alex, I Tuleta, V Harikrishnan… - Journal of the …, 2022 - Am Heart Assoc
Background In the myocardium, pericytes are often confused with other interstitial cell types,
such as fibroblasts. The lack of well‐characterized and specific tools for identification …

[HTML][HTML] Emerging role of pericytes and their secretome in the heart

H Su, AC Cantrell, H Zeng, SH Zhu, JX Chen - Cells, 2021 - mdpi.com
Pericytes, as mural cells covering microvascular capillaries, play an essential role in
vascular remodeling and maintaining vascular functions and blood flow. Pericytes are …

[HTML][HTML] Pathological roles of oxidative stress in cardiac microvascular injury

J Hou, Y Yuan, P Chen, K Lu, Z Tang, Q Liu… - Current Problems in …, 2023 - Elsevier
Cardiac microvascular injury can be a fundamental pathological process that causes high
incidence cardiovascular diseases such heart failure, diabetic cardiomyopathy, and …

The pericyte microenvironment during vascular development

LB Payne, H Zhao, CC James, J Darden… - …, 2019 - Wiley Online Library
Vascular pericytes provide critical contributions to the formation and integrity of the blood
vessel wall within the microcirculation. Pericytes maintain vascular stability and homeostasis …

Repair of the infarcted heart: cellular effectors, molecular mechanisms and therapeutic opportunities

I Hilgendorf, S Frantz, NG Frangogiannis - Circulation Research, 2024 - Am Heart Assoc
The adult mammalian heart has limited endogenous regenerative capacity and heals
through the activation of inflammatory and fibrogenic cascades that ultimately result in the …

Biology and function of pericytes in the vascular microcirculation

Y Wu, J Fu, Y Huang, R Duan, W Zhang… - Animal Models and …, 2023 - Wiley Online Library
Pericytes are the main cellular components of tiny arteries and capillaries. Studies have
found that pericytes can undergo morphological contraction or relaxation under stimulation …