The fate and role of the pericytes in myocardial diseases

NG Frangogiannis - European Journal of Clinical Investigation, 2024 - Wiley Online Library
The adult mammalian heart contains a large population of pericytes that play important roles
in homeostasis and disease. In the normal heart, pericytes regulate microvascular …

Lipidomic Predictors of Coronary No-Reflow

A Surendran, U Ismail, N Atefi, AK Bagchi, PK Singal… - Metabolites, 2023 - mdpi.com
The 'no-reflow'phenomenon (NRP) after primary percutaneous coronary intervention (PCI) is
a serious complication among acute ST-segment elevation myocardial infarction (STEMI) …

[HTML][HTML] Acoustic trauma causes cochlear pericyte-to-myofibroblast–like cell transformation and vascular degeneration, and transplantation of new pericytes prevents …

Z Hou, L Neng, J Zhang, J Cai, X Wang, Y Zhang… - The American Journal of …, 2020 - Elsevier
Acoustic trauma disrupts cochlear blood flow and damages sensory hair cells. Damage and
regression of capillaries after acoustic trauma have long been observed, but the underlying …

Hypoxic Inducible Factor Stabilization in Pericytes beyond Erythropoietin Production: The Good and the Bad

D Troise, B Infante, S Mercuri, C Piccoli, B Lindholm… - Antioxidants, 2024 - mdpi.com
The paracrine signaling pathways for the crosstalk between pericytes and endothelial cells
are essential for the coordination of cell responses to challenges such as hypoxia in both …

Integrated network pharmacology to investigate the mechanism of Salvia miltiorrhiza Bunge in the treatment of myocardial infarction

X Huang, M Zhang, Y Song, B Sun… - Journal of Cellular …, 2023 - Wiley Online Library
Salvia miltiorrhiza Bunge is a natural drug for treating myocardial infarction (MI). However,
the targets and mechanisms of S. miltiorrhiza Bunge in the treatment of MI are yet to be …

Role of pericytes in the initiation and propagation of spontaneous activity in the microvasculature

H Hashitani, R Mitsui - Smooth Muscle Spontaneous Activity: Physiological …, 2019 - Springer
The microvasculature is composed of arterioles, capillaries and venules. Spontaneous
arteriolar constrictions reduce effective vascular resistance to enhance tissue perfusion …

Synchrony of spontaneous Ca2+ activity in microvascular mural cells

R Mitsui, H Hashitani - Journal of Smooth Muscle Research, 2020 - jstage.jst.go.jp
Spontaneous rhythmic constrictions known as vasomotion are developed in several
microvascular beds in vivo. Vasomotion in arterioles is considered to facilitate blood flow …

Metabolic‐vascular coupling in skeletal muscle: A potential role for capillary pericytes?

E Attrill, C Ramsay, R Ross, S Richards… - Clinical and …, 2020 - Wiley Online Library
The matching of capillary blood flow to metabolic rate of the cells within organs and tissues
is a critical microvascular function which ensures appropriate delivery of hormones and …

MiR‐98‐5p promotes ischemia/reperfusion‐induced microvascular dysfunction by targeting NGF and is a potential biomarker for microvascular reperfusion

Y Hu, J Xiong, H Wen, H Wei, X Zeng - Microcirculation, 2021 - Wiley Online Library
Objective This study examined the correlation between serum miR‐98‐5p levels and indices
of microvascular reperfusion in patients undergoing primary percutaneous coronary …

The SARS-CoV-2 spike protein disrupts the cooperative function of human cardiac pericytes-endothelial cells through CD147 receptor-mediated signalling: a potential …

E Avolio, M Gamez, K Gupta, R Foster, I Berger… - Biorxiv, 2020 - biorxiv.org
Background Severe coronavirus disease 2019 (COVID-19) manifests as a life-threatening
microvascular syndrome. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV …