Purinergic signalling: therapeutic developments
G Burnstock - Frontiers in pharmacology, 2017 - frontiersin.org
Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …
proposed in 1972. However, this concept was not well accepted until the early 1990's when …
Adenosine and inflammation: here, there and everywhere
S Pasquini, C Contri, PA Borea, F Vincenzi… - International journal of …, 2021 - mdpi.com
Adenosine is a ubiquitous endogenous modulator with the main function of maintaining
cellular and tissue homeostasis in pathological and stress conditions. It exerts its effect …
cellular and tissue homeostasis in pathological and stress conditions. It exerts its effect …
How does adenosine control neuronal dysfunction and neurodegeneration?
RA Cunha - Journal of neurochemistry, 2016 - Wiley Online Library
The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …
The neuroprotective effects of caffeine in neurodegenerative diseases
M Kolahdouzan, MJ Hamadeh - CNS neuroscience & …, 2017 - Wiley Online Library
Caffeine is the most widely used psychostimulant in Western countries, with antioxidant, anti‐
inflammatory and anti‐apoptotic properties. In Alzheimer's disease (AD), caffeine is …
inflammatory and anti‐apoptotic properties. In Alzheimer's disease (AD), caffeine is …
Adenosine as a multi-signalling guardian angel in human diseases: when, where and how does it exert its protective effects?
The importance of adenosine for human health cannot be overstated. Indeed, this ubiquitous
nucleoside is an integral component of ATP, and regulates the function of every tissue and …
nucleoside is an integral component of ATP, and regulates the function of every tissue and …
Caffeine and its antioxidant properties—it is all about dose and source
Caffeine is the most frequently used substance with a central nervous system stimulant
effect, but its consumption is most often due to the intake of foods and drinks that contain it …
effect, but its consumption is most often due to the intake of foods and drinks that contain it …
The role of the ATP-adenosine axis in ischemic stroke
IS Schädlich, R Winzer, J Stabernack, E Tolosa… - Seminars in …, 2023 - Springer
In ischemic stroke, the primary neuronal injury caused by the disruption of energy supply is
further exacerbated by secondary sterile inflammation. The inflammatory cascade is largely …
further exacerbated by secondary sterile inflammation. The inflammatory cascade is largely …
Anti-inflammatory effects of marine bioactive compounds and their potential as functional food ingredients in the prevention and treatment of neuroinflammatory …
M Elbandy - Molecules, 2022 - mdpi.com
Functional foods include enhanced, enriched, fortified, or whole foods that impart health
benefits beyond their nutritional value, particularly when consumed as part of a varied diet …
benefits beyond their nutritional value, particularly when consumed as part of a varied diet …
Purinergic signalling in brain ischemia
Ischemia is a multifactorial pathology characterized by different events evolving in the time.
After ischemia a primary damage due to the early massive increase of extracellular …
After ischemia a primary damage due to the early massive increase of extracellular …
Aging-related metabolic dysfunction in the salivary gland: a review of the literature
NK Toan, SG Ahn - International Journal of Molecular Sciences, 2021 - mdpi.com
Aging-related salivary dysfunction commonly induces the poor oral health, including
decreased saliva flow and dental caries. Although the clinical significance of the salivary …
decreased saliva flow and dental caries. Although the clinical significance of the salivary …