Revisiting the mechanisms of immune evasion employed by human parasites

M Chulanetra, W Chaicumpa - Frontiers in cellular and infection …, 2021 - frontiersin.org
For the establishment of a successful infection, ie, long-term parasitism and a complete life
cycle, parasites use various diverse mechanisms and factors, which they may be inherently …

ROS and Trypanosoma cruzi: Fuel to infection, poison to the heart

CN Paiva, E Medei, MT Bozza - PLoS Pathogens, 2018 - journals.plos.org
The activation of macrophage respiratory burst in response to infection with Trypanosoma
cruzi inflicts oxidative damage to the host's tissues. For decades, the role of reactive oxygen …

Dual and opposite roles of reactive oxygen species (ROS) in Chagas disease: beneficial on the pathogen and harmful on the host

E Maldonado, DA Rojas, S Morales… - Oxidative Medicine …, 2020 - Wiley Online Library
Chagas disease is a neglected tropical disease, which affects an estimate of 6‐7 million
people worldwide. Chagas disease is caused by Trypanosoma cruzi, which is a eukaryotic …

Inhibitory effects of oxali-Platin as a chemotherapeutic drug on the function and structure of bovine liver catalase

O Abazari, A Divsalar, R Ghobadi - Journal of Biomolecular …, 2020 - Taylor & Francis
Full article: Inhibitory effects of oxali-Platin as a chemotherapeutic drug on the function and
structure of bovine liver catalase Skip to Main Content Taylor and Francis Online homepage …

The role of Acanthamoeba castellanii (T4 genotype) antioxidant enzymes in parasite survival under H2O2-induced oxidative stress

S Motavallihaghi, I Khodadadi, F Goudarzi… - Parasitology …, 2022 - Elsevier
Acanthamoeba castellanii (A. castellanii) is an important opportunistic parasite. Induction of
oxidative stress by the host immune system is one of the most important defense strategies …

Catalase compromises the development of the insect and mammalian stages of Trypanosoma brucei

E Horáková, D Faktorová, N Kraeva, B Kaur… - The FEBS …, 2020 - Wiley Online Library
Catalase is a widespread heme‐containing enzyme, which converts hydrogen peroxide
(H2O2) to water and molecular oxygen, thereby protecting cells from the toxic effects of …

Oxidative stress, cardiomyocytes premature senescence and contractile dysfunction in in vitro and in vivo experimental models of Chagas disease

SS Nogueira, MA Souza, EC Santos, IS Caldas… - Acta Tropica, 2023 - Elsevier
Aims The relationship between redox imbalance and cardiovascular senescence in
infectious myocarditis is unknown. Thus, the aim of this study was to investigate whether …

Comparative analysis of three trypanosomatid catalases of different origin

Ľ Chmelová, C Bianchi, ATS Albanaz, J Režnarová… - Antioxidants, 2021 - mdpi.com
Most trypanosomatid flagellates do not have catalase. In the evolution of this group, the
gene encoding catalase has been independently acquired at least three times from three …

DNA lesions and repair in trypanosomatids infection

BM Repolês, CR Machado… - Genetics and Molecular …, 2020 - SciELO Brasil
Pathological processes such as bacterial, viral and parasitic infections can generate a
plethora of responses such as, but not restricted to, oxidative stress that can be harmful to …

Catalase impairs Leishmania mexicana development and virulence

J Sádlová, L Podešvová, T Bečvář, C Bianchi… - Virulence, 2021 - Taylor & Francis
Catalase is one of the most abundant enzymes on Earth. It decomposes hydrogen peroxide,
thus protecting cells from dangerous reactive oxygen species. The catalase-encoding gene …