The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

1. After 50 years of antipsychotic drug development focused on the dopamine D2 receptor,
schizophrenia remains a chronic, disabling disorder for most affected individuals. 2. Studies …

The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different
CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy …

The human glycine transporter 1 (GlyT1) regulates glycine-mediated neuronal excitation
and inhibition through the sodium-and chloride-dependent reuptake of glycine,–. Inhibition …

The small intestine mediates the absorption of amino acids after ingestion of protein and
sustains the supply of amino acids to all tissues. The small intestine is an important …

Glycine transporters are endogenous regulators of the dual functions of glycine, which acts
as a classical inhibitory neurotransmitter at glycinergic synapses and as a modulator of …

Synaptic transmission between midbrain dopamine neurons and target neurons in the
striatum is essential for the selection and reinforcement of movements. Recent evidence …

Changes in the response to release of a single synaptic vesicle have generally been
attributed to postsynaptic modification of receptor sensitivity, but considerable evidence now …

Rhythmic spontaneous electrical activity occurs in many parts of the developing nervous
system, where it plays essential roles in the refinement of neural connections. By blocking or …

Astroglial excitability is largely mediated by fluctuations in intracellular ion concentrations. In
addition to generally acknowledged Ca 2+ excitability of astroglia, recent studies have …