Serum urate has been implicated in hypertension and cardiovascular disease, but it is not
known whether it is exerting a causal effect. To investigate this, we performed Mendelian …

Background Allopurinol is a urate-lowering therapy used to treat patients with gout. Previous
studies have shown that allopurinol has positive effects on several cardiovascular …

Background: We conducted meta-analyses to identify relationships between obstructive
sleep apnea (OSA) severity, muscle sympathetic nerve activity (MSNA), and blood pressure …

Chronic intermittent hypoxia (CIH) is the dominant pathological feature of human obstructive
sleep apnoea (OSA), which is highly prevalent and associated with cardiovascular and renal …

Objective: Obstructive sleep apnoea (OSA) is a common cause of secondary hypertension.
This network meta-analysis (NMA) assessed the effect of different OSA treatments on …

Key points The carotid chemoreceptor mediates the ventilatory and muscle sympathetic
nerve activity (MSNA) responses to hypoxia and contributes to tonic sympathetic and …

BACKGROUND Allopurinol is a xanthine oxidase inhibitor that lowers serum uric acid and is
used to prevent acute gout flares in patients with gout. Observational and small …

From a physiological point of view, peripheral chemoreceptors (PCh) are the main sensors
of hypoxia in mammals and are responsible for adaptation to hypoxic conditions. Their …

The carotid body (CB) is an important organ located at the carotid bifurcation that constantly
monitors the blood supplying the brain. During hypoxia, the CB immediately triggers an …

Aims We analysed longitudinal blood pressure (BP) data from hypertensive obstructive
sleep apnoea (OSA) patients in the European Sleep Apnea Database cohort. The study …