CRISPR/Cas9 screen reveals that targeting TRIM34 enhances ferroptosis sensitivity and augments immunotherapy efficacy in hepatocellular carcinoma
F Yao, S Zhou, R Zhang, Y Chen, W Huang, K Yu… - Cancer Letters, 2024 - Elsevier
Hepatocellular carcinoma (HCC) is a prevalent malignancy characterized by complex
heterogeneity and drug resistance. Resistance to ferroptosis is closely related to the …
heterogeneity and drug resistance. Resistance to ferroptosis is closely related to the …
Metallothionein-3 is a multifunctional driver that modulates the development of sorafenib-resistant phenotype in hepatocellular carcinoma cells
MAM Rodrigo, H Michalkova, AMJ Jimenez… - Biomarker …, 2024 - Springer
Abstract Background & aims Metallothionein-3 (hMT3) is a structurally unique member of the
metallothioneins family of low-mass cysteine-rich proteins. hMT3 has poorly characterized …
metallothioneins family of low-mass cysteine-rich proteins. hMT3 has poorly characterized …
Antitumor activity of genetically engineered NK-cells in non-hematological solid tumor: a comprehensive review
CP Dash, D Sonowal, P Dhaka, R Yadav… - Frontiers in …, 2024 - frontiersin.org
Recent advancements in genetic engineering have made it possible to modify Natural Killer
(NK) cells to enhance their ability to fight against various cancers, including solid tumors …
(NK) cells to enhance their ability to fight against various cancers, including solid tumors …
The Role of TLR4 in the Immunotherapy of Hepatocellular Carcinoma: Can We Teach an Old Dog New Tricks?
Simple Summary In this study, we investigated the potential of TLR4 to improve the
treatment of hepatocellular carcinoma (HCC). HCC is a serious health concern worldwide …
treatment of hepatocellular carcinoma (HCC). HCC is a serious health concern worldwide …
hccTAAb Atlas: An Integrated Knowledge Database for Tumor-Associated Autoantibodies in Hepatocellular Carcinoma
T Li, P Wang, G Sun, Y Zou, Y Cheng… - Journal of Proteome …, 2023 - ACS Publications
Tumor-associated autoantibodies (TAAbs) have demonstrated potential as biomarkers for
cancer detection. However, the understanding of their role in hepatocellular carcinoma …
cancer detection. However, the understanding of their role in hepatocellular carcinoma …
Hepatitis B virus pathogenesis relevant immunosignals uncovering amino acids utilization related risk factors guide artificial intelligence-based precision medicine
J Huang, C Zhao, X Zhang, Q Zhao, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Background: Although immune microenvironment-related chemokines, extracellular matrix
(ECM), and intrahepatic immune cells are reported to be highly involved in hepatitis B virus …
(ECM), and intrahepatic immune cells are reported to be highly involved in hepatitis B virus …
[HTML][HTML] Arenobufagin Enhances T-cell Anti-Tumor Immunity in Colorectal Cancer by Modulating HSP90β Accessibility
Z Shang, Y Fan, S Xi, S Zhang, W Shen, L Tao, C Xu… - Phytomedicine, 2024 - Elsevier
Background Colorectal cancer (CRC) is a significant public health issue, ranking as one of
the predominant cancer types globally in terms of incidence. Intriguingly, Arenobufagin …
the predominant cancer types globally in terms of incidence. Intriguingly, Arenobufagin …
[HTML][HTML] Combating drug resistance in hepatocellular carcinoma: No awareness today, no action tomorrow
F Jing, X Li, H Jiang, J Sun, Q Guo - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Hepatocellular carcinoma (HCC), the sixth most common cancer worldwide, is associated
with a high degree of malignancy and poor prognosis. Patients with early HCC may benefit …
with a high degree of malignancy and poor prognosis. Patients with early HCC may benefit …
Strategies and Recent Advances on Improving Efficient Antitumor of Lenvatinib Based on Nanoparticle Delivery System
H Wang, W Bo, X Feng, J Zhang, G Li… - International Journal of …, 2024 - Taylor & Francis
Lenvatinib (LVN) is a potentially effective multiple-targeted receptor tyrosine kinase inhibitor
approved for treating hepatocellular carcinoma, metastatic renal cell carcinoma and thyroid …
approved for treating hepatocellular carcinoma, metastatic renal cell carcinoma and thyroid …
Hepatocellular Carcinoma and the Multifaceted Relationship with Its Microenvironment: Attacking the Hepatocellular Carcinoma Defensive Fortress
Simple Summary The microenvironment of hepatocellular carcinoma is a really complex
milieu, containing a wide variety of cells with specific tasks, belonging to both the …
milieu, containing a wide variety of cells with specific tasks, belonging to both the …