Background and Purpose—In patients receiving direct oral anticoagulants (DOACs),
emergency treatment like thrombolysis for acute ischemic stroke is complicated by …

The perioperative management of dabigatran is challenging, and recommendations based
on activated partial thromboplastin time (aPTT) and thrombin time (TT) are unsatisfactory …

Anticoagulant drugs have been used to prevent and treat thrombosis. However, they are
associated with risk of hemorrhage. Therefore, prior to their clinical use, it is important to …

Background: The utility of measuring non-vitamin K antagonist oral anticoagulants (NOACs)
in plasma, serum and urine samples and with the point-of-care test (POCT) on urine …

Essentials• Anticoagulants need to be stopped preprocedure so there is little or no
remaining anticoagulant effect.• We assessed the residual anticoagulant effect with …

Non‐VKA oral anticoagulants (NOACs) have now widely reached the lucrative market of
anticoagulation. While the marketing authorization holders claimed that no routine …

Major orthopaedic surgery is associated with an increased risk of venous thromboembolism.
Direct oral anticoagulants (DOACs) are recommended as thromboprophylactic agents after …

Background The use of direct oral anticoagulants (DOACs) is a convenient therapeutic
option for patients at risk of thrombosis. DOACs interfere with clot‐based testing for the …

Background: Clinicians managing patients receiving the direct thrombin inhibitor dabigatran
may benefit in being able to determine the amount of drug present in selected situations …

Guidance regarding dabigatran monitoring has been published [1, 2], but the specific assays
are not all targeted to low levels of dabigatran encountered in the preoperative setting. For …