Functions of double‐negative B cells in autoimmune diseases, infections, and cancers

MKY Chung, L Gong, DLW Kwong, VHF Lee… - EMBO Molecular …, 2023 - embopress.org
Most mature B cells can be divided into four subtypes based on the expression of the
surface markers IgD and CD27: IgD+ CD27− naïve B cells, IgD+ CD27+ unswitched memory …

SARS-CoV-2 Omicron BA. 1 breakthrough infection drives late remodeling of the memory B cell repertoire in vaccinated individuals

A Sokal, G Barba-Spaeth, L Hunault, I Fernández… - Immunity, 2023 - cell.com
How infection by a viral variant showing antigenic drift impacts a preformed mature human
memory B cell (MBC) repertoire remains an open question. Here, we studied the MBC …

[HTML][HTML] Antigen presentation dynamics shape the antibody response to variants like SARS-CoV-2 Omicron after multiple vaccinations with the original strain

L Yang, M Van Beek, Z Wang, F Muecksch, M Canis… - Cell Reports, 2023 - cell.com
The Omicron variant of SARS-CoV-2 is not effectively neutralized by most antibodies elicited
by two doses of mRNA vaccines, but a third dose increases anti-Omicron neutralizing …

[HTML][HTML] Antigen presentation dynamics shape the response to emergent variants like SARS-CoV-2 Omicron strain after multiple vaccinations with wild type strain

L Yang, M Van Beek, Z Wang, F Muecksch, M Canis… - bioRxiv, 2022 - ncbi.nlm.nih.gov
The Omicron variant of SARS-CoV-2 evades neutralization by most serum antibodies
elicited by two doses of mRNA vaccines, but a third dose of the same vaccine increases anti …

The impact of antigenic distance on Orthopoxvirus Vaccination and Mpox Infection for cross-protective immunity

J Crandell, VS Monteiro, L Pischel, Z Fang, Y Zhong… - medRxiv, 2024 - medrxiv.org
Immunological memory mediates rapid protection following infection or vaccination
including heterologous exposure. However, cross-reactive memory responses in humans …

[HTML][HTML] Two-dose “extended priming” immunization amplifies humoral immune responses by synchronizing vaccine delivery with the germinal center response

SH Bhagchandani, L Yang, L Maiorino, E Ben-Akiva… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Abstract “Extended priming” immunization regimens that prolong exposure of the immune
system to vaccines during the primary immune response have shown promise in enhancing …

Omicron BA. 1 breakthrough infection drives long-term remodeling of the memory B cell repertoire in vaccinated individuals

A Sokal, G Barba-Spaeth, L Hunault, I Fernández… - bioRxiv, 2023 - biorxiv.org
How infection by a viral variant showing antigenic drift impacts a preformed mature human
memory B cell (MBC) repertoire remains an open question. Here, we studied the MBC …

Detection of Humoral Response to Transgene Protein and Gene Editing Reagents

G Buchlis, B Gorovits - Drug Development for Gene Therapy …, 2024 - Wiley Online Library
Assessment of the impact of immune responses against Adeno‐associated virus (AAV)
therapeutics needs to include immunity to the transgene product encoded by the AAV vector …

Investigation of the frequencies of various B cell populations in non-responder healthcare workers in comparison with responders to hepatitis B virus vaccination

S Karimi, F Mehdipour, J Sarvari… - Transactions of The …, 2023 - academic.oup.com
Background Hepatitis B is a major global health problem. More than 90% of hepatitis B-
vaccinated immunocompetent adults become fully immune. The main purpose of …

Detection of Humoral Response to Transgene

G Buchlis¹, B Gorovits - Drug Development for Gene Therapy …, 2024 - books.google.com
Much emphasis on the development of gene therapies has been placed on measuring,
avoiding, and/or limiting immune responses to the viral capsid. While anti-capsid immune …