Guidelines aim to improve the quality of medical care and reduce treatment variation. The
extent to which guidelines are adhered to in the field of traumatic brain injury (TBI) is …

Background Hypochlorhydric states are an important cause of iron deficiency (ID).
Nevertheless, the association between therapy with proton pump inhibitors (PPI s) and ID …

Comorbidity scores are widely used to help address confounding bias in nonrandomized
studies conducted within health-care databases, but existing scores were developed to …

Purpose Depression is a prevalent health problem affecting US women. Oral contraceptive
pills (OCPs) are commonly used for pregnancy prevention, and evidence is mixed regarding …

Background Decision makers in health care increasingly rely on nonrandomized database
analyses to assess the effectiveness, safety, and value of medical products. Health care data …

Objective: Patients with major depression discontinue taking their antidepressants for many
reasons. Although side effects are often cited as the reason for discontinuation, few …

Background There is growing epidemiological evidence that opioids may increase the risk of
unintentional injuries and it is plausible that the time of initiation is most critical in that …

We used data from a large, prospective Canadian cohort to assess the association between
selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake …

In the study of the association of transient drug exposures with acute outcomes, the case-
crossover design is an efficient alternative to the case-control approach. This design based …

Importance A comprehensive meta-analysis of randomized trial data suggests that suicidal
behavior is twice as likely when children and young adults are randomized to …