Chimeric antigen receptor T cells (CAR-T) therapy has achieved remarkable therapeutic
success in treating a variety of hematopoietic malignancies. However, the high relapse rate …

Amplifying free radical production by chemical dynamic catalysis to cause oxidative damage
to cancer cells has received extensive interest for cancer‐specific therapy. The major …

T cells are the key players in eliminating malignant tumors. Adoptive transfer of tumor
antigen-specific T cells and immune checkpoint blockade has yielded durable antitumor …

Recent evidence supports the notion that mitochondrial metabolism is necessary for T cell
activation, proliferation, and function. Mitochondrial metabolism supports T cell anabolism by …

Significance: Thioredoxin (Trx) is a powerful antioxidant that reduces protein disulfides to
maintain redox stability in cells and is involved in regulating multiple redox-dependent …

Oxidative stress is a state of imbalance between oxidation and antioxidation. Excessive ROS
levels are an important factor in tumor development. Damage stimulation and excessive …

The increased production of derivatives of molecular oxygen and nitrogen in the form of
reactive oxygen species (ROS) and reactive nitrogen species (RNS) lead to molecular …

The plasma membrane proteome is a rich resource of functionally important and
therapeutically relevant protein targets. Distinguished by high hydrophobicity, heavy …

Recent studies have shown a correlation between COVID-19, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and the distinct, exaggerated …

Because of the central role ribosomes play for protein translation and ribosome-mediated
mRNA and protein quality control (RQC), the ribosome pool is surveyed and dysfunctional …