Ketone bodies are crucial intermediate metabolites widely associated with treating
metabolic diseases. Accumulating evidence suggests that ketone bodies may act as …

Gastrointestinal cancer causes countless deaths every year due to therapeutic resistance.
However, whether metabolic alterations contribute to chemoresistance is not well …

Mitochondrial activation and the production of mitochondrial reactive oxygen species
(mROS) are crucial for CD4+ T cell responses and have a role in naïve cell signaling after …

Pyruvate dehydrogenase (PDH) is the central enzyme connecting glycolysis and the
tricarboxylic acid (TCA) cycle. The importance of PDH function in T helper 17 (Th17) cells …

SARS-CoV2 infection or COVID-19 has created panic around the world since its first origin
in December 2019 in Wuhan city, China. The COVID-19 pandemic has infected more than …

The microenvironment of most tumors is complex, comprising numerous aspects of
immunosuppression. Several studies have indicated that the adrenergic system is vital for …

The intestinal microbiota is essential for the fermentation of dietary fiber into short-chain fatty
acids (SCFA) such as butyrate, acetate, and propionate. SCFAs can bind to the G-protein …

T helper 17 (TH17) cells are implicated in autoimmune diseases, and several metabolic
processes are shown to be important for their development and function. In this study, we …

Purpose Acute lung injury (ALI) is a life-threatening condition with limited therapeutic
options. Macrophage inflammation plays a key role in the development of ALI. Abnormal …

Sepsis has always been considered as a big challenge for pharmaceutical companies in
terms of discovering and designing new therapeutics. The pathogenesis of sepsis involves …