The development of immune checkpoint blockade (ICB) therapies has been instrumental in
advancing the field of immunotherapy. Despite the prominence of these treatments, many …

Visible light (VL) surely affects human skin in several ways, exerting positive (tissue
regeneration, pain relief) and negative (oxidation, inflammation) effects, depending on the …

Oxidative stress induced by excess reactive oxygen species (ROS) is a primary pathogenic
cause of acute kidney injury (AKI). Development of an effective antioxidation system to …

Extracellular regulated protein kinases (ERK) signaling is a master regulator of cell
behavior, life, and fate. Although ERK pathway is shown to be involved in T‐cell activation …

Malaria represents a major cause of death from infectious disease. Hemozoin is a
Plasmodium-derived product that contributes to progression of cerebral malaria. However …

The core catalytic unit of telomerase comprises telomerase reverse transcriptase (TERT)
and telomerase RNA (TERC). Unlike TERT, which is predominantly expressed in cancer …

Recent advances in immunotherapies such as immune checkpoint blockade (ICB) and
chimeric antigen receptor T cells (CAR-T) for the treatment of cancer have generated …

Abstract Rationale: Regulatory T cells (Treg cells) play an important role in maintaining
peripheral tolerance by suppressing over-activation of effector T cells. The kinase PDK1 …

Simple Summary Tumor immune evasion is one of the hallmarks of tumor progression that
enables tumor growth despite the activity of the host immune system. It is mediated by …

Chronic autoimmune diseases are associated with mutations in PTPN22, a modifier of T cell
receptor (TCR) signaling. As with all protein tyrosine phosphatases, the activity of PTPN22 is …