With regard to the varied, nonculinary uses of hot pepper, there is apparently little new under
the sun. For example, Incas burned dried chili peppers to combat the invading Spaniards by …

Despite the progress that has occurred in recent years in the development of therapy, there
is still a need for effective and potent analgesics, especially for the treatment of chronic pain …

Vanilloid receptor type 1 (VR1)(TRPV1) is a ligand-gated ion channel expressed on sensory
nerves that responds to noxious heat, protons, and chemical stimuli such as capsaicin …

The vanilloid receptor 1 (VR1) is a cation channel expressed predominantly by nociceptive
sensory neurons and is activated by a wide array of pain-producing stimuli, including …

Members of the transient receptor potential (TRP) family of nonselective cation channels are
involved in several pathological and physiological conditions. The search for the molecular …

Capsaicin, the active ingredient in hot chilli peppers, has selective actions on unmyelinated
C-fibres and thinly myelinated A primary sensory neurones [37, 100](Table 1). Most …

The mechanisms underlying the response of airway afferent nerves to low pH were
investigated in an isolated guinea‐pig airway nerve preparation. Extracellular recordings …

Actions of capsaicin were examined on synaptic transmissions in the substantia gelatinosa
(SG) of adult rat spinal cord slices using the whole-cell patch-recording technique. Bath …

Since cloning and characterizing the first nociceptive ion channel Transient Receptor
Potential (TRP) Vanilloid 1 (TRPV1), other TRP channels involved in nociception have been …

A fundamental subdivision of nociceptive sensory neurons is named after their unique
sensitivity to capsaicin, the pungent ingredient in hot chili peppers: these are the capsaicin …