Amyotrophic lateral sclerosis

EL Feldman, SA Goutman, S Petri, L Mazzini… - The Lancet, 2022 - thelancet.com
Amyotrophic lateral sclerosis is a fatal CNS neurodegenerative disease. Despite intensive
research, current management of amyotrophic lateral sclerosis remains suboptimal from …

Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation

RJ Mead, N Shan, HJ Reiser, F Marshall… - Nature Reviews Drug …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …

Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis

SA Goutman, O Hardiman, A Al-Chalabi… - The Lancet …, 2022 - thelancet.com
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease. The discovery of genes
associated with amyotrophic lateral sclerosis, commencing with SOD1 in 1993, started fairly …

Neurodegenerative disease among male elite football (soccer) players in Sweden: a cohort study

P Ueda, B Pasternak, CE Lim, M Neovius… - The Lancet Public …, 2023 - thelancet.com
Background Football (soccer) players might be at increased risk of neurodegenerative
disease, which has led to questions regarding the safety of the sport and recent measures …

The protective role of exercise against age-related neurodegeneration

A Sujkowski, L Hong, RJ Wessells, SV Todi - Ageing Research Reviews, 2022 - Elsevier
Endurance exercise is a widely accessible, low-cost intervention with a variety of benefits to
multiple organ systems. Exercise improves multiple indices of physical performance and …

The amyotrophic lateral sclerosis exposome: recent advances and future directions

SA Goutman, MG Savelieff, DG Jang, J Hur… - Nature Reviews …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal disease of motor neuron degeneration with
typical survival of only 2–5 years from diagnosis. The causes of ALS are multifactorial …

Nutritional and metabolic factors in amyotrophic lateral sclerosis

A Ludolph, L Dupuis, E Kasarskis, F Steyn… - Nature Reviews …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease that is
classically thought to impact the motor system. Over the past 20 years, research has started …

Unraveling the complex interplay between genes, environment, and climate in ALS

R Vasta, R Chia, BJ Traynor, A Chio - EBioMedicine, 2022 - thelancet.com
Various genetic and environmental risk factors have been implicated in the pathogenesis of
amyotrophic lateral sclerosis (ALS). Despite this, the cause of most ALS cases remains …

A review of Mendelian randomization in amyotrophic lateral sclerosis

TH Julian, S Boddy, M Islam, J Kurz, KJ Whittaker… - Brain, 2022 - academic.oup.com
Amyotrophic lateral sclerosis is a relatively common and rapidly progressive
neurodegenerative disease that, in the majority of cases, is thought to be determined by a …

The role of DNA damage in neural plasticity in physiology and neurodegeneration

A Konopka, JD Atkin - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Damage to DNA is generally considered to be a harmful process associated with aging and
aging-related disorders such as neurodegenerative diseases that involve the selective …