Medicinal chemistry updates on quinoline-and endoperoxide-based hybrids with potent antimalarial activity
The resistance of conventional antimalarial drugs against the malarial parasite continues to
pose a challenge to control the disease. The indiscriminate exploitation of the available …
pose a challenge to control the disease. The indiscriminate exploitation of the available …
Direct Sequencing of Cryptosporidium in Stool Samples for Public Health
The protozoan parasite Cryptosporidium is an important cause of diarrheal disease
(cryptosporidiosis) in humans and animals, with significant morbidity and mortality especially …
(cryptosporidiosis) in humans and animals, with significant morbidity and mortality especially …
3D-QSAR, docking and ADMET properties of aurone analogues as antimalarial agents
H Hadni, M Elhallaoui - Heliyon, 2020 - cell.com
The development of multi-resistant strains of plasmodium parasite has become a global
problem, therefore, the discovery of new antimalarial agents is the only available solution. In …
problem, therefore, the discovery of new antimalarial agents is the only available solution. In …
2D and 3D-QSAR, molecular docking and ADMET properties in silico studies of azaaurones as antimalarial agents
H Hadni, M Elhallaoui - New Journal of Chemistry, 2020 - pubs.rsc.org
Malaria persists as the most infectious vector-borne disease in the world. The inhibition of
the mitochondrial respiratory chain enzyme cytochrome bc1 has become the major focus as …
the mitochondrial respiratory chain enzyme cytochrome bc1 has become the major focus as …
3D-QSAR, molecular docking, DFT and ADMET studies on quinazoline derivatives to explore novel DHFR inhibitors
H Hadni, M Bakhouch, M Elhallaoui - Journal of Biomolecular …, 2023 - Taylor & Francis
Resistance to folate antagonists is caused by mutations in the dihydrofolate reductase
(DHFR) genes. These mutations affect the amino acids at positions 51, 59, 108 and 164 of …
(DHFR) genes. These mutations affect the amino acids at positions 51, 59, 108 and 164 of …
Determinants of Plasmodium falciparum multiplicity of infection and genetic diversity in Burkina Faso
P Sondo, K Derra, T Rouamba, S Nakanabo Diallo… - Parasites & vectors, 2020 - Springer
Background Investigating malaria transmission dynamics is essential to inform policy
decision making. Whether multiplicity of infection (MOI) dynamic from individual infections …
decision making. Whether multiplicity of infection (MOI) dynamic from individual infections …
Genomic malaria surveillance of antenatal care users detects reduced transmission following elimination interventions in Mozambique
N Brokhattingen, G Matambisso, C da Silva… - Nature …, 2024 - nature.com
Routine sampling of pregnant women at first antenatal care (ANC) visits could make
Plasmodium falciparum genomic surveillance more cost-efficient and convenient in sub …
Plasmodium falciparum genomic surveillance more cost-efficient and convenient in sub …
Diversity and Multiplicity of P. falciparum infections among asymptomatic school children in Mbita, Western Kenya
Multiplicity of infection (MOI) and genetic diversity of P. falciparum infections are important
surrogate indicators for assessing malaria transmission intensity in different regions of …
surrogate indicators for assessing malaria transmission intensity in different regions of …
Genetic diversity of Plasmodium falciparum and genetic profile in children affected by uncomplicated malaria in Cameroon
TN Metoh, JH Chen, P Fon-Gah, X Zhou… - Malaria Journal, 2020 - Springer
Background Malaria is a major public health problem in Cameroon. The study of the genetic
diversity within parasite population is essential for understanding the mechanism underlying …
diversity within parasite population is essential for understanding the mechanism underlying …
Malaria genomics, vaccine development, and microbiome
Recent advances in malaria genetics and genomics have transformed many aspects of
malaria research in areas of molecular evolution, epidemiology, transmission, host–parasite …
malaria research in areas of molecular evolution, epidemiology, transmission, host–parasite …