Medicinal chemistry updates on quinoline-and endoperoxide-based hybrids with potent antimalarial activity

A Uddin, M Chawla, I Irfan, S Mahajan… - RSC Medicinal …, 2021 - pubs.rsc.org
The resistance of conventional antimalarial drugs against the malarial parasite continues to
pose a challenge to control the disease. The indiscriminate exploitation of the available …

Direct Sequencing of Cryptosporidium in Stool Samples for Public Health

A Morris, G Robinson, MT Swain… - Frontiers in Public …, 2019 - frontiersin.org
The protozoan parasite Cryptosporidium is an important cause of diarrheal disease
(cryptosporidiosis) in humans and animals, with significant morbidity and mortality especially …

3D-QSAR, docking and ADMET properties of aurone analogues as antimalarial agents

H Hadni, M Elhallaoui - Heliyon, 2020 - cell.com
The development of multi-resistant strains of plasmodium parasite has become a global
problem, therefore, the discovery of new antimalarial agents is the only available solution. In …

2D and 3D-QSAR, molecular docking and ADMET properties in silico studies of azaaurones as antimalarial agents

H Hadni, M Elhallaoui - New Journal of Chemistry, 2020 - pubs.rsc.org
Malaria persists as the most infectious vector-borne disease in the world. The inhibition of
the mitochondrial respiratory chain enzyme cytochrome bc1 has become the major focus as …

3D-QSAR, molecular docking, DFT and ADMET studies on quinazoline derivatives to explore novel DHFR inhibitors

H Hadni, M Bakhouch, M Elhallaoui - Journal of Biomolecular …, 2023 - Taylor & Francis
Resistance to folate antagonists is caused by mutations in the dihydrofolate reductase
(DHFR) genes. These mutations affect the amino acids at positions 51, 59, 108 and 164 of …

Determinants of Plasmodium falciparum multiplicity of infection and genetic diversity in Burkina Faso

P Sondo, K Derra, T Rouamba, S Nakanabo Diallo… - Parasites & vectors, 2020 - Springer
Background Investigating malaria transmission dynamics is essential to inform policy
decision making. Whether multiplicity of infection (MOI) dynamic from individual infections …

Genomic malaria surveillance of antenatal care users detects reduced transmission following elimination interventions in Mozambique

N Brokhattingen, G Matambisso, C da Silva… - Nature …, 2024 - nature.com
Routine sampling of pregnant women at first antenatal care (ANC) visits could make
Plasmodium falciparum genomic surveillance more cost-efficient and convenient in sub …

Diversity and Multiplicity of P. falciparum infections among asymptomatic school children in Mbita, Western Kenya

AO Touray, VA Mobegi, F Wamunyokoli, JK Herren - Scientific reports, 2020 - nature.com
Multiplicity of infection (MOI) and genetic diversity of P. falciparum infections are important
surrogate indicators for assessing malaria transmission intensity in different regions of …

Genetic diversity of Plasmodium falciparum and genetic profile in children affected by uncomplicated malaria in Cameroon

TN Metoh, JH Chen, P Fon-Gah, X Zhou… - Malaria Journal, 2020 - Springer
Background Malaria is a major public health problem in Cameroon. The study of the genetic
diversity within parasite population is essential for understanding the mechanism underlying …

Malaria genomics, vaccine development, and microbiome

X Su, RV Stadler, F Xu, J Wu - Pathogens, 2023 - mdpi.com
Recent advances in malaria genetics and genomics have transformed many aspects of
malaria research in areas of molecular evolution, epidemiology, transmission, host–parasite …