Protective role and functional engineering of neuropeptides in depression and anxiety: an overview

N Okdeh, G Mahfouz, J Harb, JM Sabatier, R Roufayel… - Bioengineering, 2023 - mdpi.com
Behavioral disorders, such as anxiety and depression, are prevalent globally and touch
children and adults on a regular basis. Therefore, it is critical to comprehend how these …

Application of intranasal administration in the delivery of antidepressant active ingredients

Z Jin, Y Han, D Zhang, Z Li, Y Jing, B Hu, S Sun - Pharmaceutics, 2022 - mdpi.com
As a mental disease in modern society, depression shows an increasing occurrence, with
low cure rate and high recurrence rate. It has become the most disabling disease in the …

Arsenic exposure induced anxiety-like behaviors in male mice via influencing the GABAergic Signaling in the prefrontal cortex

X Hu, X Yuan, M Yang, M Han, MM Ommati… - … Science and Pollution …, 2023 - Springer
Arsenic contamination in drinking water causes a global public health problem. Emerging
evidence suggests that arsenic may act as an environmental risk factor for anxiety disorders …

Melanin-concentrating hormone promotes anxiety and intestinal dysfunction via basolateral amygdala in mice

X He, Y Li, N Zhang, J Huang, X Ming, R Guo… - Frontiers in …, 2022 - frontiersin.org
The limbic system plays a pivotal role in stress-induced anxiety and intestinal disorders, but
how the functional circuits between nuclei within the limbic system are engaged in the …

Anxiety and depression: what do we know of neuropeptides?

I Kupcova, L Danisovic, I Grgac, S Harsanyi - Behavioral Sciences, 2022 - mdpi.com
In modern society, there has been a rising trend of depression and anxiety. This trend
heavily impacts the population's mental health and thus contributes significantly to morbidity …

The melanin-concentrating hormone system as a target for the treatment of sleep disorders

LE Potter, CR Burgess - Frontiers in neuroscience, 2022 - frontiersin.org
Given the widespread prevalence of sleep disorders and their impacts on health, it is critical
that researchers continue to identify and evaluate novel avenues of treatment. Recently the …

Melanin-concentrating hormone receptor: A therapeutic target for novel anxiolytics

S Chaki - Pharmacology Biochemistry and Behavior, 2024 - Elsevier
Anxiety disorders are chronic, disabling psychiatric disorders, and there is a growing
medical need for the development of novel pharmacotherapeutic agents showing improved …

Ventral hippocampal NMDA receptors mediate the effects of nicotine on stress-induced anxiety/exploratory behaviors in rats

P Farzamfard, A Rezayof, S Alijanpour - Neuroscience Letters, 2022 - Elsevier
Brief exposure to stress increases the tendency to drug abuse, especially cigarette smoking.
It seems that nicotine abuse alleviates some psychological and physiological stress …

The immunogenetics of alopecia areata

F Rajabi, F Abdollahimajd, N Jabalameli… - The Immunogenetics of …, 2022 - Springer
Alopecia areata (AA) is an autoimmune disease that targets the hair follicles (HF) and results
in non-scarring hair loss. AA results from the collapse of the HF's immune privilege due to a …

Pesticide-Induced Alterations in Locomotor Activity, Anxiety, and Depression-like Behavior Are Mediated through Oxidative Stress-Related Autophagy: A Persistent …

MM Ommati, Z Nozhat, S Sabouri, X Kong… - Journal of agricultural …, 2024 - ACS Publications
Chlorpyrifos (CPF), dichlorvos (DDV), and cypermethrin (CP), as commonly used pesticides,
have been implicated in inducing neuropsychiatric disorders, such as anxiety, depression …