Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription
factors that regulate gene expression following ligand activation. PPARα increases cellular …

The evolutionary pressure for life transitioning from extended periods of hypoxia to an
increasingly oxygenated atmosphere initiated drastic selections for a variety of biochemical …

The ketone bodies beta-hydroxybutyrate and acetoacetate are hepatically produced
metabolites catabolized in extrahepatic organs. Ketone bodies are a critical cardiac fuel and …

Metabolic networks are interconnected and influence diverse cellular processes. The protein-
metabolite interactions that mediate these networks are frequently low affinity and …

As a result of metabolic reprogramming, cancer cells display high rates of glycolysis,
causing an excess production of lactate along with an increase in extracellular acidity …

Cardiac metabolism is vital for heart function. Given that cardiac contraction requires a
continuous supply of ATP in large quantities, the role of fuel metabolism in the heart has …

The sarcomeric interaction of α-myosin heavy chain (α-MHC) with Titin is vital for cardiac
structure and contraction. However, the mechanism regulating this interaction in normal and …

Sepsis is involved in~ 20% of annual global deaths. Despite decades of research, the
current management of sepsis remains supportive rather than curative. Clinical trials in …

The heart requires fatty acids to maintain its activity. Various mechanisms regulate
myocardial fatty acid metabolism, such as energy production using fatty acids as fuel, for …