Astrocytes are the most numerous type of neuroglia in the brain and have a predominant
influence on the cerebrovascular system; they control perivascular homeostasis, the integrity …

Emerging evidence suggests that crosstalk between glioma cells and the brain
microenvironment may influence brain tumor growth. To date, known reciprocal interactions …

A hallmark of astrocytic tumors is their infiltrative nature. Although their aggressive and
typically widespread dispersal in the adult brain differs fundamentally from that of other brain …

Reactive astrocytes are integral to the glioma microenvironment. Connexin43 (Cx43) is a
major gap junction protein in astrocytes and its expression is enhanced significantly in …

The invasiveness of high-grade glioma is the primary reason for poor survival following
treatment. Interaction between glioma cells and surrounding astrocytes are crucial to …

Cancer was one of the first pathologies to be associated with gap-junction defect. Despite
the evidence accumulated over the last 40-year period, the molecular involvement of gap …

Gap junctions are intercellular channels which directly connect the cytoplasm between
neighboring cells. In the central nervous system (CNS) various kinds of cells are coupled by …

Brain inflammation is characterized by a reactive gliosis involving the activation of astrocytes
and microglia. This process, common to many brain injuries and diseases, underlies …

F10 and BL6 sublines of B16 mouse melanoma cells are metastatic after intravenous
injection, but only BL6 cells are metastatic after subcutaneous injection. We found that …

Diffuse gliomas are primary brain tumors associated with a poor prognosis. Cellular and
molecular mechanisms driving the invasive growth patterns and therapeutic resistance are …