Cognitive dysfunction in major depressive disorder

MJ Knight, BT Baune - Current opinion in psychiatry, 2018 - journals.lww.com
A growing interest in cognitive dysfunction in MDD has improved our ability to assess and
treat MDD. Future research will be strengthened by the use of consistent terminology …

A meta-analysis of the effects of antidepressants on cognitive functioning in depressed and non-depressed samples

CE Prado, S Watt, SF Crowe - Neuropsychology review, 2018 - Springer
A thorough understanding of the cognitive effects of antidepressant medications is essential
given their frequency of use. This meta-analysis was conducted to investigate whether …

A randomized, placebo-controlled, active-reference, double-blind, flexible-dose study of the efficacy of vortioxetine on cognitive function in major depressive disorder

AR Mahableshwarkar, J Zajecka, W Jacobson… - …, 2015 - nature.com
This multicenter, randomized, double-blind, placebo-controlled, active-referenced
(duloxetine 60 mg), parallel-group study evaluated the short-term efficacy and safety of …

The effects of vortioxetine on cognitive function in patients with major depressive disorder: a meta-analysis of three randomized controlled trials

RS McIntyre, J Harrison, H Loft… - International Journal …, 2016 - academic.oup.com
Background: Management of cognitive deficits in Major Depressive Disorder (MDD) remains
an important unmet need. This meta-analysis evaluated the effects of vortioxetine on …

A network meta-analysis comparing effects of various antidepressant classes on the digit symbol substitution test (DSST) as a measure of cognitive dysfunction in …

BT Baune, M Brignone, KG Larsen - International Journal of …, 2018 - academic.oup.com
Background Major depressive disorder is a common condition that often includes cognitive
dysfunction. A systematic literature review of studies and a network meta-analysis were …

Altered γ-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic …

AL Pehrson, C Sanchez - Drug design, development and therapy, 2015 - Taylor & Francis
Evidence suggesting that central nervous system γ-aminobutyric acid (GABA)
concentrations are reduced in patients with major depressive disorder (MDD) has been …

Fluoxetine and Vortioxetine Reverse Depressive-Like Phenotype and Memory Deficits Induced by Aβ1-42 Oligomers in Mice: A Key Role of Transforming Growth …

SA Torrisi, F Geraci, MR Tropea, M Grasso… - Frontiers in …, 2019 - frontiersin.org
Depression is a risk factor for the development of Alzheimer's disease (AD), and the
presence of depressive symptoms significantly increases the conversion of mild cognitive …

Serotonergic regulation of prefrontal cortical circuitries involved in cognitive processing: a review of individual 5-HT receptor mechanisms and concerted effects of 5 …

SC Leiser, Y Li, AL Pehrson, E Dale… - ACS chemical …, 2015 - ACS Publications
It has been known for several decades that serotonergic neurotransmission is a key
regulator of cognitive function, mood, and sleep. Yet with the relatively recent discoveries of …

Vortioxetine: a new treatment for major depressive disorder

KR Connolly, ME Thase - Expert Opinion on Pharmacotherapy, 2016 - Taylor & Francis
Introduction: Vortioxetine is a structurally novel medication that has recently been approved
for treatment of major depressive disorder (MDD). This medication is a serotonin reuptake …

[HTML][HTML] A comprehensive review and meta-analysis of neurological side effects related to second-generation antidepressants in individuals with major depressive …

Q Zhou, X Li, D Yang, C Xiong, Z Xiong - Behavioural Brain Research, 2023 - Elsevier
Second-generation antidepressants (SGADs) often cause neurological side effects (SEs).
This meta-analysis seeks to quantify the short-term rates of neurological SEs related to …