In cell and molecular biology, metabolism is the only system that can be fully simulated at
genome scale. Metabolic systems biology offers powerful abstraction tools to simulate all …

Alcoholic fermentation is a crucial step of winemaking, during which yeasts convert sugars to
alcohol and also produce or biotransform numerous flavour compounds. In this context …

Constraint-based models of metabolism are a widely used framework for predicting flux
distributions in genome-scale biochemical networks. The number of published methods for …

Many cell biological and biochemical mechanisms controlling the fundamental process of
eukaryotic cell division have been identified; however, the temporal dynamics of biosynthetic …

Yeast is an ideal organism for the development and application of synthetic biology, yet
there remain relatively few well-characterised biological parts suitable for precise …

Nutrient sensing and metabolic reprogramming are crucial for metazoan cell aging and
tumor growth. Here, we identify metabolic and regulatory parallels between a layered …

The mold Aspergillus fumigatus is the most important airborne fungal pathogen. Adaptation
to hypoxia represents an important virulence attribute for A. fumigatus. Therefore, we aimed …

The sequential or co-inoculation of grape must with non-Saccharomyces yeast species and
Saccharomyces cerevisiae wine yeast strains has recently become a common practice in …

Motivation Transcriptomics and proteomics data have been integrated into constraint-based
models to influence flux predictions. However, it has been reported recently for Escherichia …

Motivation: Integration of different biological networks and data-types has been a major
challenge in systems biology. The present study introduces the transcriptional regulated flux …