It has been well-documented that the brain changes in states of chronic pain. Less is known
about changes in the brain that predict the transition from acute to chronic pain. Evidence …

Conditioned pain modulation (CPM) describes the reduction in pain evoked by a test
stimulus (TS) when presented together with a heterotopic painful conditioning stimulus (CS) …

Purpose: To 1) examine whether blood flow restriction would provide an additional exercise-
induced hypoalgesic response at an upper and lower limb when it is incorporated with low …

Cancer survivorship represents a growing clinical challenge for pain clinicians. The
population of cancer survivors is rapidly expanding and many of these patients experience …

Background Isometric exercises decrease pressure pain sensitivity in exercising and
nonexercising muscles known as exercise-induced hypoalgesia (EIH). No studies have …

Abstract Introduction Peripheral nerve injuries (PNIs) cause both structural and functional
brain changes that may be associated with significant sensorimotor abnormalities and pain …

Objective Physically active individuals show greater conditioned pain modulation (CPM)
compared with less active individuals. Understanding the effects of acute exercise on CPM …

Musculoskeletal pain is an extensive societal challenge, due to the large population
affected, an increased expected life span, and the lack of efficient prevention and treatment …

This Phase II study evaluated analgesia, abuse liability, and cognitive performance of
hydromorphone and oral delta-9-tetrahydrocannabinol (THC; dronabinol) using a within …

Background Duloxetine is indicated in the management of pain in osteoarthritis. Evidence
suggests that duloxetine modulates central pain mechanisms and cognitive factors, and …