Low back pain (LBP) has been inconsistently associated with enhanced pronociceptive and
impaired antinociceptive mechanisms. It remains unknown whether alterations are causal …

Traumatic injuries affect approximately 978 million people worldwide with 56.2 million
requiring inpatient care. Quantitative sensory testing (QST) can be useful in predicting …

Distinct pain experiences are shaped both by personal attributes and characteristics of
noxious stimuli. An Individual's capacity for endogenous pain inhibition (reflected by …

Methods: Sixty-seven middle-aged and older adults with chronic musculoskeletal pain were
recruited from the community. Questionnaires measuring demographics, pain, and …

Abstract Background and Objective Chronic pain following musculoskeletal trauma is
common, which may partially be attributed to the early presence of central sensitization (CS) …

Background Conditioned pain modulation (CPM) and offset analgesia quantify impairment
of endogenous pain modulation, but magnitude and reliability vary broadly between studies …

Objective Pain is a significant burden for patients with rheumatoid arthritis (RA) despite
advancements in treatment. We undertook this study to examine the independent …

The descending pain modulatory system in humans is commonly investigated using
conditioned pain modulation (CPM). Whilst variability in CPM efficiency, ie, inhibition and …

Neuropathic pain in children can be severe and persistent, difficult to recognise and
manage, and associated with significant pain-related disability. Recognition based on …

Abstract Native Americans (NAs) have a higher prevalence of chronic pain than other US
racial/ethnic groups, but there have been few attempts to understand the mechanisms of this …