[HTML][HTML] Analyzing FDA-approved drugs for compliance of pharmacokinetic principles: should there be a critical screening parameter in drug designing protocols?
S Pathania, PK Singh - Expert Opinion on Drug Metabolism & …, 2021 - Taylor & Francis
In this era, rational drug designing protocols involve an insilico virtual screening process of
evaluating a library of molecular structures to enhance the speed of the drug discovery …
evaluating a library of molecular structures to enhance the speed of the drug discovery …
Overview on synthesis, reactions, applications, and biological activities of Schiff bases
SS Mukhtar, AS Hassan, NM Morsy… - Egyptian Journal of …, 2021 - ejchem.journals.ekb.eg
Schiff bases exhibited various pharmacological and biological activities such as
antibacterial, cytotoxic effects, antifungal, and antimalarial. Schiff bases were used for …
antibacterial, cytotoxic effects, antifungal, and antimalarial. Schiff bases were used for …
[HTML][HTML] Exploring novel derivatives of isatin-based Schiff bases as multi-target agents: design, synthesis, in vitro biological evaluation, and in silico ADMET analysis …
Recently, scientists developed a powerful strategy called “one drug-multiple targets” to
discover vital and unique therapies to fight the most challenging diseases. Novel derivatives …
discover vital and unique therapies to fight the most challenging diseases. Novel derivatives …
In vitro enzymatic evaluation of some pyrazolo[1,5‐a]pyrimidine derivatives: Design, synthesis, antioxidant, anti‐diabetic, anti‐Alzheimer, and anti‐arthritic activities …
AS Hassan, NM Morsy… - Drug Development …, 2023 - Wiley Online Library
The strategy of utilizing nitrogen compounds in various biological applications has recently
emerged as a powerful approach to exploring novel classes of therapeutics to face the …
emerged as a powerful approach to exploring novel classes of therapeutics to face the …
Synthesis, molecular docking, and in silico ADME prediction of some fused pyrazolo[1,5-a]pyrimidine and pyrazole derivatives as potential antimicrobial agents
Abstract Twenty compounds of pyrazolo [1, 5-a] pyrimidines 14a–j and pyrazole derivatives
as Schiff bases 16a–j have been synthesized by the reaction of 5-amino-pyrazole …
as Schiff bases 16a–j have been synthesized by the reaction of 5-amino-pyrazole …
QSAR, homology modeling, and docking simulation on SARS-CoV-2 and pseudomonas aeruginosa inhibitors, ADMET, and molecular dynamic simulations to find a …
Background In seek of potent and non-toxic iminoguanidine derivatives formerly assessed
as active Pseudomonas aeruginosa inhibitors, a combined mathematical approach of …
as active Pseudomonas aeruginosa inhibitors, a combined mathematical approach of …
Synthesis, antitumor activity, enzyme assay, DNA binding and molecular docking of Bis-Schiff bases of pyrazoles
NM Morsy, AS Hassan, TS Hafez, MRH Mahran… - Journal of the Iranian …, 2021 - Springer
A novel series of Bis-Schiff bases of pyrazoles 9–24 were synthesized by the direct
condensation of 5-aminopyrazoles 4a–d with dialdehydes 8a–d in ethanol. The newly …
condensation of 5-aminopyrazoles 4a–d with dialdehydes 8a–d in ethanol. The newly …
Design, synthesis and antibacterial activity of N-aryl-3-(arylamino)-5-(((5-substituted furan-2-yl) methylene) amino)-1H-pyrazole-4-carboxamide as Nitrofurantoin® …
AS Hassan, GO Moustafa, NM Morsy… - Egyptian Journal of …, 2020 - ejchem.journals.ekb.eg
Nitrofurantoin® is an effective drug and used for treating urinary infectious diseases. A
series of nitrofurantoin® analogues bearing furan and pyrazole scaffolds as N-aryl-3 …
series of nitrofurantoin® analogues bearing furan and pyrazole scaffolds as N-aryl-3 …
phytochemdb: a platform for virtual screening and computer-aided drug designing
The phytochemicals of medicinal plants are regarded as a rich source of diverse chemical
spaces that have been used as supplements and alternative medicines in the millennium …
spaces that have been used as supplements and alternative medicines in the millennium …
A Computational Study on Selected Alkaloids as SARS‐CoV‐2 Inhibitors: PASS Prediction, Molecular Docking, ADMET Analysis, DFT, and Molecular Dynamics …
Despite treatments and vaccinations, it remains difficult to develop naturally occurring
COVID‐19 inhibitors. Here, our main objective is to find potential lead compounds from the …
COVID‐19 inhibitors. Here, our main objective is to find potential lead compounds from the …