[HTML][HTML] Futile cycles: Emerging utility from apparent futility
AK Sharma, R Khandelwal, C Wolfrum - Cell Metabolism, 2024 - cell.com
Futile cycles are biological phenomena where two opposing biochemical reactions run
simultaneously, resulting in a net energy loss without appreciable productivity. Such a state …
simultaneously, resulting in a net energy loss without appreciable productivity. Such a state …
[HTML][HTML] Molecular Regulation of Thermogenic Mechanisms in Beige Adipocytes
S Yang, Y Liu, X Wu, R Zhu, Y Sun, S Zou… - International Journal of …, 2024 - mdpi.com
Adipose tissue is conventionally recognized as a metabolic organ responsible for storing
energy. However, a proportion of adipose tissue also functions as a thermogenic organ …
energy. However, a proportion of adipose tissue also functions as a thermogenic organ …
Short-term cold exposure induces persistent epigenomic memory in brown fat
Deficiency of the epigenome modulator histone deacetylase 3 (HDAC3) in brown adipose
tissue (BAT) impairs the ability of mice to survive in near-freezing temperatures. Here, we …
tissue (BAT) impairs the ability of mice to survive in near-freezing temperatures. Here, we …
[HTML][HTML] A novel fatty acid mimetic with pan-PPAR partial agonist activity inhibits diet-induced obesity and metabolic dysfunction-associated steatotic liver disease
Objective The prevalence of metabolic diseases is increasing globally at an alarming rate;
thus, it is essential that effective, accessible, low-cost therapeutics are developed …
thus, it is essential that effective, accessible, low-cost therapeutics are developed …
[HTML][HTML] Adipsin and adipocyte-derived C3aR1 regulate thermogenic fat in a sex-dependent fashion
L Ma, A Gilani, A Rubio-Navarro, E Cortada, A Li… - JCI …, 2024 - Am Soc Clin Investig
JCI Insight - Adipsin and adipocyte-derived C3aR1 regulate thermogenic fat in a sex-dependent
fashion Go to The Journal of Clinical Investigation About Editors Consulting Editors For …
fashion Go to The Journal of Clinical Investigation About Editors Consulting Editors For …
UCP1 and CKB are parallel players in BAT
M Dong, Z Cheng, W Jin - Cell Metabolism, 2024 - Elsevier
It is generally believed that the contributions of the UCP1-independent thermogenic
pathways are secondary to UCP1-mediated thermogenesis in BAT. Now, Rahbani et al …
pathways are secondary to UCP1-mediated thermogenesis in BAT. Now, Rahbani et al …
[PDF][PDF] Adaptive Induction of Nonshivering Thermogenesis in Muscle Rather Than Brown Fat Could Counteract Obesity
K Bardova, P Janovska, A Vavrova, J Kopecky… - Physiological …, 2024 - biomed.cas.cz
Warm-blooded animals such as birds and mammals are able to protect stable body
temperature due to various thermogenic mechanisms. These processes can be facultative …
temperature due to various thermogenic mechanisms. These processes can be facultative …
[引用][C] BAT-tling oxidative stress through BCAA catabolism
M Delgado-Martin, Q Zhang, L Kazak - Life Metabolism, 2024 - academic.oup.com
Elevated circulating levels of branched-chain amino acids (BCAAs) are associated with the
development of type 2 diabetes and obesity, diseases that can be countered by the energy …
development of type 2 diabetes and obesity, diseases that can be countered by the energy …