Chronic lung disease determines the morbidity and mortality of cystic fibrosis (CF) patients.
The pulmonary immune response in CF is characterized by an early and non-resolving …

With the improving survival of cystic fibrosis (CF) patients and the advent of highly effective
cystic fibrosis transmembrane conductance regulator (CFTR) therapy, the clinical spectrum …

Objective To evaluate the generation of rheumatoid arthritis (RA)–related autoantibodies in
the lung. Methods Simultaneous collection of serum and induced sputum was performed in …

Rationale: Recent evidence from clinical studies suggests that neutrophil elastase (NE)
released in neutrophilic airway inflammation is a key risk factor for the onset and …

Rationale: Cystic fibrosis (CF) is a life-shortening, multisystem hereditary disease caused by
abnormal chloride transport. CF lung disease is driven by innate immune dysfunction and …

Neutrophil elastase (NE) is a key risk factor for severity of cystic fibrosis (CF) lung disease.
Recent studies identified increased NE activity on the surface of airway neutrophils from CF …

Pseudomonas aeruginosa can cause major infection in immunocompromised patients, and
successful antibiotic treatment of the infection relies on accurate and rapid identification of …

Rationale: Glutathione is the major antioxidant in the extracellular lining fluid of the lungs
and depleted in patients with cystic fibrosis (CF). Objectives: We aimed to assess glutathione …

BACKGROUND: Previous studies have indicated that oxidative stress plays an important
role in the pathogenesis of chronic obstructive pulmonary disease (COPD). OBJECTIVES …

BACKGROUND: Few data exist on the functional activity of airway neutrophils in the milieu
of the cystic fibrosis (CF) lung. We assessed reactive oxygen species (ROS) production by …