Anti-inflammatory and cytoprotective actions of hydrogen sulfide: translation to therapeutics
Significance: There is a rapidly expanding body of evidence for important roles of hydrogen
sulfide in protecting against tissue injury, reducing inflammation, and promoting repair …
sulfide in protecting against tissue injury, reducing inflammation, and promoting repair …
[HTML][HTML] A multi-targeted approach to suppress tumor-promoting inflammation
Cancers harbor significant genetic heterogeneity and patterns of relapse following many
therapies are due to evolved resistance to treatment. While efforts have been made to …
therapies are due to evolved resistance to treatment. While efforts have been made to …
The role of inflammation in kidney cancer
AR de Vivar Chevez, J Finke, R Bukowski - Inflammation and Cancer, 2014 - Springer
Renal cell carcinoma (RCC) constitutes more than 90% of primary kidney tumors with the
development of metastatic disease in the lung, bone, liver, and brain. Clear-cell RCC …
development of metastatic disease in the lung, bone, liver, and brain. Clear-cell RCC …
COX‐2 inhibitors and gastric cancer
Z Wang, J Chen, J Liu - Gastroenterology research and practice, 2014 - Wiley Online Library
The evidence that cyclooxygenase‐2 (COX‐2) is upregulated and plays an important role in
carcinogenesis of gastric cancer has triggered the topic of COX‐2 inhibitors as …
carcinogenesis of gastric cancer has triggered the topic of COX‐2 inhibitors as …
Celecoxib and octreotide synergistically ameliorate portal hypertension via inhibition of angiogenesis in cirrhotic rats
Abnormal angiogenesis is critical for portal hypertension in cirrhosis. Except for etiological
treatment, no efficient medication or regime has been explored to treat the early stage of …
treatment, no efficient medication or regime has been explored to treat the early stage of …
Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis
Background Increased intra-hepatic resistance to portal blood flow is the primary factor
leading to portal hypertension in cirrhosis. Up-regulated expression of cyclooxygenase-2 …
leading to portal hypertension in cirrhosis. Up-regulated expression of cyclooxygenase-2 …
[HTML][HTML] Paeonol exerts an anticancer effect on human colorectal cancer cells through inhibition of PGE2 synthesis and COX-2 expression
M Li, SY Tan, XF Wang - Oncology reports, 2014 - spandidos-publications.com
Abstract Cyclooxygenase-2 (COX-2) and its metabolite prostaglandin E2 (PGE2) can
potentially affect most of the events in cancer development, including promotion of …
potentially affect most of the events in cancer development, including promotion of …
Celecoxib attenuates hepatic cirrhosis through inhibition of epithelial‐to‐mesenchymal transition of hepatocytes
SL Wen, JH Gao, WJ Yang, YY Lu… - Journal of …, 2014 - Wiley Online Library
Abstract Background and Aim The epithelial–mesenchymal transition (EMT) of hepatocytes
is a key step for hepatic fibrosis and cirrhosis. Long‐term administration of celecoxib, a …
is a key step for hepatic fibrosis and cirrhosis. Long‐term administration of celecoxib, a …
Enhanced chemopreventive effects of a hydrogen sulfide-releasing anti-inflammatory drug (ATB-346) in experimental colorectal cancer
Regular use of nonsteroidal anti-inflammatory drugs is associated with a significantly lower
incidence of several types of cancer, particularly those affecting the gastrointestinal tract …
incidence of several types of cancer, particularly those affecting the gastrointestinal tract …
Pathway analysis for drug repositioning based on public database mining
Y Pan, T Cheng, Y Wang, SH Bryant - Journal of chemical …, 2014 - ACS Publications
Sixteen FDA-approved drugs were investigated to elucidate their mechanisms of action
(MOAs) and clinical functions by pathway analysis based on retrieved drug targets …
(MOAs) and clinical functions by pathway analysis based on retrieved drug targets …