Background and objectives Acute traumatic coagulopathy (ATC) has been reported in the
setting of isolated traumatic brain injury (iTBI) and associated with high mortality and poor …

Traumatic injury is a common cause of coagulopathy, primarily due to blood loss and
hemodilution secondary to fluid resuscitation. Traumatic injury-associated coagulopathy …

To provide guidance to clinicians, the Wilderness Medical Society (WMS) convened an
expert panel to develop evidence-based guidelines for the out-of-hospital evaluation and …

Background Life-threatening haemorrhage accounts for 40% mortality in trauma patients
worldwide. After bleeding control is achieved, circulating volume must be restored. Early in …

The human body strives at maintaining homeostasis within fairly tight regulated mechanisms
that control vital regulators such as core body temperature, mechanisms of metabolism and …

Acidosis, hypothermia and hypocalcaemia are determinants for morbidity and mortality
during massive hemorrhages. However, precise pathological mechanisms of these …

To provide guidance to clinicians, the Wilderness Medical Society convened an expert panel
to develop evidence-based guidelines for the out-of-hospital evaluation and treatment of …

Peripheral and central immune cells are critical for fighting disease, but they can also play a
pivotal role in the onset and/or progression of a variety of neurological conditions that affect …

Damage control resuscitation should be initiated as soon as possible after a trauma event to
avoid metabolic decompensation and high mortality rates. The aim of this article is to assess …

Background Arterial base deficit (BD) has been widely used in trauma patients since 1960.
However, trauma management has also evolved significantly in the last 2 decades. The first …