The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

Nanomedicine has emerged as a promising mean to improve theranostic efficacy and
reduce side effects. Currently, only very small percentage of injected dose reaches the solid …

Cancer is a major threat to human health. Among various treatment methods, precision
therapy has received significant attention since the inception, due to its ability to efficiently …

Nuclear targeting of therapeutics provides a strategy for enhancing efficacy of molecules
active in the nucleus and minimizing off-target effects.'Active'nuclear-directed transport and …

The development of carrier systems that are able to transport and release therapeutics to
target cells is an emergent strategy to treat cancer; however, they following endocytosis are …

Mitochondria are implicated in a wide range of functions apart from ATP generation, and,
therefore, constitute one of the most important organelles of cell. Since healthy mitochondria …

Nanoparticles (NPs) for delivering chemotherapeutic drugs are now in clinical trials, and
cellular uptake of NPs plays an important role in determining the drug delivery efficiency …

The combination therapy with different treatment modalities has been widely applied in the
clinical applications of cancer treatment. However, it stills a considerable challenge to …

Despite their clinical success in drug delivery applications, the potential of theranostic
nanomedicines is hampered by mechanistic uncertainty and a lack of science-informed …

Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide and its
incidence is increasing due to the ageing population. Currently, the main limitations of AD …