A guide to plasma membrane solute carrier proteins
MD Pizzagalli, A Bensimon… - The FEBS …, 2021 - Wiley Online Library
This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …
of transporter proteins and their roles in human cells. The SLC superfamily currently …
Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets
GM Mawe, JM Hoffman - Nature reviews Gastroenterology & hepatology, 2013 - nature.com
Abstract Serotonin (5-HT) has been recognized for decades as an important signalling
molecule in the gut, but it is still revealing its secrets. Novel gastrointestinal functions of 5-HT …
molecule in the gut, but it is still revealing its secrets. Novel gastrointestinal functions of 5-HT …
X-ray structures and mechanism of the human serotonin transporter
The serotonin transporter (SERT) terminates serotonergic signalling through the sodium-and
chloride-dependent reuptake of neurotransmitter into presynaptic neurons. SERT is a target …
chloride-dependent reuptake of neurotransmitter into presynaptic neurons. SERT is a target …
Mechanisms of dopamine transporter regulation in normal and disease states
RA Vaughan, JD Foster - Trends in pharmacological sciences, 2013 - cell.com
The dopamine (DA) transporter (DAT) controls the spatial and temporal dynamics of DA
neurotransmission by driving reuptake of extracellular transmitter into presynaptic neurons …
neurotransmission by driving reuptake of extracellular transmitter into presynaptic neurons …
SLC6 transporters: structure, function, regulation, disease association and therapeutics
The SLC6 family of secondary active transporters are integral membrane solute carrier
proteins characterized by the Na+-dependent translocation of small amino acid or amino …
proteins characterized by the Na+-dependent translocation of small amino acid or amino …
The solute carrier 6 family of transporters
The solute carrier 6 (SLC6) family of the human genome comprises transporters for
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family …
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family …
Structural basis for recognition of diverse antidepressants by the human serotonin transporter
JA Coleman, E Gouaux - Nature structural & molecular biology, 2018 - nature.com
Selective serotonin reuptake inhibitors are clinically prescribed antidepressants that act by
increasing the local concentrations of neurotransmitters at synapses and in extracellular …
increasing the local concentrations of neurotransmitters at synapses and in extracellular …
Neuropeptide and small transmitter coexistence: fundamental studies and relevance to mental illness
Neuropeptides are auxiliary messenger molecules that always co-exist in nerve cells with
one or more small molecule (classic) neurotransmitters. Neuropeptides act both as …
one or more small molecule (classic) neurotransmitters. Neuropeptides act both as …
Monoamine transporters and psychostimulant addiction
LL Howell, HL Kimmel - Biochemical pharmacology, 2008 - Elsevier
Psychostimulants are a broadly defined class of drugs that stimulate the central and
peripheral nervous systems as their primary pharmacological effect. The abuse liability of …
peripheral nervous systems as their primary pharmacological effect. The abuse liability of …
Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2, 4, 6-trinitrobenzene sulfonic acid colitis in mice
SC Bischoff, R Mailer, O Pabst… - American Journal …, 2009 - journals.physiology.org
Serotonin (5-HT) regulates peristaltic and secretory reflexes in the gut. The serotonin
reuptake transporter (SERT; SLC6A4), which inactivates 5-HT, is expressed in the intestinal …
reuptake transporter (SERT; SLC6A4), which inactivates 5-HT, is expressed in the intestinal …