Aqueous prostaglandin eye drop formulations

P Jansook, T Loftsson - Pharmaceutics, 2022 - mdpi.com
Glaucoma is one of the leading causes of irreversible blindness worldwide. It is
characterized by progressive optic neuropathy in association with damage to the optic nerve …

Recently approved drugs for lowering and controlling intraocular pressure to reduce vision loss in ocular hypertensive and glaucoma patients

NA Sharif - Pharmaceuticals, 2023 - mdpi.com
Serious vision loss occurs in patients affected by chronically raised intraocular pressure
(IOP), a characteristic of many forms of glaucoma where damage to the optic nerve …

[HTML][HTML] A novel fixed-combination timolol-netarsudil-latanoprost ophthalmic solution for the treatment of glaucoma and ocular hypertension

T Wang, Y Zhang, M Chi, C Zhao, L Cao, C Tian… - Asian Journal of …, 2022 - Elsevier
Currently commercial fixed-concomitant three agents have multiple problems such as
multiple dosing administration, poor efficacy and side effects. Once-daily fixed-combination …

The role of conventional and unconventional adaptive routes in lowering of intraocular pressure: Theoretical model and simulation

R Sacco, G Chiaravalli, G Antman, G Guidoboni… - Physics of …, 2023 - pubs.aip.org
In this article, we propose a theoretical model leveraging the analogy between fluid and
electric variables to investigate the relation among aqueous humor (AH) circulation and …

How latanoprost changed glaucoma management

MF Cordeiro, S Gandolfi, K Gugleta… - Acta …, 2024 - Wiley Online Library
Glaucoma is currently considered one of the leading causes of severe visual impairment
and blindness worldwide. Topical medical therapy represents the treatment of choice for …

Effect of a fixed combination of ripasudil and brimonidine on aqueous humor dynamics in mice

R Yamagishi-Kimura, M Honjo, M Aihara - Scientific Reports, 2024 - nature.com
Ripasudil–brimonidine fixed-dose combination (K-232) simultaneously targets three
different intraocular pressure (IOP) lowering mechanisms, increasing trabecular meshwork …

[HTML][HTML] Advancing ophthalmic delivery of flurbiprofen via synergistic chiral resolution and ion-pairing strategies

Z Ma, Y Wang, H He, T Liu, Q Jiang, X Hou - Asian Journal of …, 2024 - Elsevier
Flurbiprofen (FB), a nonsteroidal anti-inflammatory drug, is widely employed in treating
ocular inflammation owing to its remarkable anti-inflammatory effects. However, the racemic …

Modification of contact lenses via metal‐organic frameworks for glaucoma treatment

AV Yaremenko, RO Melikov, NA Pechnikova… - …, 2024 - Wiley Online Library
The prevention of blindness from glaucoma requires multiple treatments to lower intraocular
pressure. Here, human contact lenses are modified with highly porous metal‐organic …

Currently available prostanoids for the treatment of glaucoma and ocular hypertension: A review

B Benitez, AM Anter, J Arcuri… - Current opinion in …, 2024 - Elsevier
Recent advancements in prostaglandin analogs (PGAs) have reinforced their role in
managing intraocular pressure (IOP). Latanoprost excels in 24-h IOP control, while various …

Electrosprayed core-shell nanoparticles for sustained release fixed combination monotherapy in glaucoma treatment

G Kumari, TSS Kumar, M Zare… - Journal of Drug Delivery …, 2023 - Elsevier
Glaucoma, leading to progressive partial or complete blindness, is a matter of serious
concern worldwide. Although avoidable with right diagnosis and continuous treatment, a …