Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

Vascular dementia (VaD) is a second most common form of age-related dementia. It is
characterized by cognitive impairment associated with vascular pathology, symptoms mainly …

Background Microglial-mediated neuroinflammation plays an important role in vascular
dementia, and modulating neuroinflammation has emerged as a promising treatment target …

Disordered lipid accumulation in the arterial wall is a hallmark of atherosclerosis. Previous
studies found that the expression of triggering receptor expressed on myeloid cells 2 …

Diabetes mellitus is associated with cognitive impairment characterized by memory loss and
cognitive inflexibility. Recent studies have revealed that ChemR23 is implicated in both …

Parkinson's disease (PD) is mainly characterized by the progressive degeneration of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) and neuroinflammation …

Background Alzheimer's disease (AD) represents the common neurodegenerative disease
featured by the manifestations of cognitive impairment and memory loss. AD could be …

Obesity is a global epidemic, affecting roughly 30% of the world's population and predicted
to rise. This disease results from genetic, behavioral, societal, and environmental factors …

Diabetes mellitus is a globally significant disease that can lead to systemic complications,
particularly vascular damage, including cardiovascular and cerebrovascular diseases of …

Background Chronic cerebral hypoperfusion (CCH) is regarded as a high-risk factor for
cognitive decline in vascular dementia (VaD). We have previously shown that diabetes …