Metabolic Profile of Alzheimer's Disease: Is 10-Hydroxy-2-decenoic Acid a Pertinent Metabolic Adjuster?

Y Gong, H Luo, Z Li, Y Feng, Z Liu, J Chang - Metabolites, 2023 - mdpi.com
Alzheimer's disease (AD) represents a significant public health concern in modern society.
Metabolic syndrome (MetS), which includes diabetes mellitus (DM) and obesity, represents …

What type of cell death occurs in chronic cerebral hypoperfusion? A review focusing on pyroptosis and its potential therapeutic implications

Y He, X Chen, M Wu, X Hou, Z Zhou - Frontiers in Cellular …, 2023 - frontiersin.org
Chronic cerebral hypoperfusion (CCH) is a major global disease with chronic cerebral blood
flow reduction. It is also the main cause of cognitive impairment and neurodegenerative …

β-Arrestin–Mediated Angiotensin II Type 1 Receptor Activation Promotes Pulmonary Vascular Remodeling in Pulmonary Hypertension

Z Ma, G Viswanathan, M Sellig, C Jassal, I Choi… - Basic to Translational …, 2021 - jacc.org
Pulmonary arterial hypertension (PAH) is a disease of abnormal pulmonary vascular
remodeling whose medical therapies are thought to primarily act as vasodilators but also …

Network pharmacology-based strategy to investigate pharmacological mechanisms of Andrographolide for treatment of vascular cognitive impairment

Y Zhao, J Zhang, Y Zhang, Y Zhang, X Zhang… - International …, 2022 - Elsevier
Vascular cognitive impairment (VCI) is the second most common form of dementia.
Andrographolide (Andro) shows potential effects in anti-inflammation, anti-oxidative stress …

Regulation of oxygen–glucose deprivation/reperfusion-induced inflammatory responses and M1-M2 phenotype switch of BV2 microglia by lobetyolin

J Wang, X Liu, W Wei, J Yang, Q Li, S Chu, P Liu… - Metabolic Brain …, 2023 - Springer
To elucidate the protective mechanism of lobetyolin on oxygen–glucose deprivation/
reperfusion (OGD/R)-induced damage in BV2 microglial cells. The OGD/R model was …

Plasticity of the spinal glymphatic system in male SD rats with painful diabetic neuropathy induced by type 2 diabetes mellitus

GQ Wang, FX Wang, YN He… - Journal of neuroscience …, 2022 - Wiley Online Library
The glymphatic system is a recently discovered glial‐dependent macroscopic interstitial
waste clearance system that promotes the efficient elimination of soluble proteins and …

Structural characterization, anti-inflammatory and glycosidase inhibitory activities of two new polysaccharides from the root of Pueraria lobata

J Cai, X Zhong, J Liang, C Xu, H Yu, M Xian, C Yan… - RSC …, 2021 - pubs.rsc.org
Diabetes seriously endangers public health and brings a heavy economic burden to the
country. Inflammation is one of the main inducing factors of type-2 diabetes (T2D) and may …

Modulatory effect of methylsulfonylmethane against BPA/γ-radiation induced neurodegenerative alterations in rats: influence of TREM-2/DAP-12/Syk pathway

MK Abdel-Rafei, NM Thabet - Life Sciences, 2020 - Elsevier
Aims Methylsulfonylmethane (MSM), is an organosulfur compound, has many health
benefits. Bisphenol-A (BPA) and γ-radiation (R) are two risky environmental contaminants …

Plasma nesfatin-1: Potential predictor and diagnostic biomarker for cognitive dysfunction in T2DM patient

D Xu, Y Yu, Y Xu, J Ge - Diabetes, Metabolic Syndrome and …, 2021 - Taylor & Francis
Purpose Nesfatin-1 plays a crucial role in glucose metabolism and cognitive function. This
study aimed to investigate the correlation between plasma nesfatin-1 levels and clinical …

YY1 promotes microglia M2 polarization through the miR-130a-3p/TREM-2 axis to alleviate sepsis-associated encephalopathy

LS Peng, Y Xu, QS Wang - Shock, 2022 - journals.lww.com
Purpose: Sepsis-associated encephalopathy (SAE) induces cognitive dysfunction via
mechanisms that commonly involve neuroinflammation. Yin Yang 1 (YY1) is an important …