Regulatory T cells (Tregs) are abundant in tumor tissues, raising a question of whether
immunosuppressive tumor-infiltrating Tregs (TI-Tregs) can be selectively depleted or …

Simple Summary Various immune cells are involved in host immune responses to cancer. T-
helper (Th) 1 cells, cytotoxic CD8+ T cells, and natural killer cells are the major effector cells …

Infiltration of regulatory T (Treg) cells, an immunosuppressive population of CD4+ T cells,
into solid cancers represents a barrier to cancer immunotherapy. Chemokine receptors are …

Simple Summary B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric
cancer. Even though the cure rate actually exceeds 85%, the prognosis of …

Adult T cell leukemia/lymphoma (ATLL) is an aggressive T-cell malignancy that develops in
some elderly human T-cell leukemia virus (HTVL-1) carriers. ATLL has a poor prognosis …

Hepatitis B virus (HBV) infection is the main risk factor for the development of hepatocellular
carcinoma (HCC), the most common type of liver cancer, with high incidence and mortality …

Aims Ischemic stroke is one of the leading causes of death worldwide and the most common
cause of disability in Western countries. Multiple mechanisms contribute to the development …

Background: Kidney renal clear cell carcinoma (KIRC) is an inflammation-related carcinoma,
and inflammation has been recognized as an important factor in inducing carcinogenesis …

The CC chemokine receptor type-4 (CCR4) belongs to the G-protein-coupled receptor
superfamily, expressed on the cell surface of T cells and its malignancy. Two CCR4 ligands …

Adult T-cell leukemia/lymphoma (ATLL), an infrequent malignancy resultant from human T-
cell lymphotropic virus type I (HTLV-1), exhibits a spectrum of phenotypes, encompassing …