Targeting the residual cardiovascular risk by specific anti-inflammatory interventions as a therapeutic strategy in atherosclerosis

A Hafiane, SS Daskalopoulou - Pharmacological Research, 2022 - Elsevier
Chronic subclinical inflammation is a key process in the pathogenesis of atherosclerotic
cardiovascular disease (ASCVD). Along with lipids, inflammation is essential for the initiation …

[HTML][HTML] The impact of mental stress on cardiovascular health—part II

MY Henein, S Vancheri, G Longo… - Journal of Clinical …, 2022 - mdpi.com
Endothelial dysfunction is one of the earliest manifestations of atherosclerosis, contributing
to its development and progression. Mental stress induces endothelial dysfunction through …

[HTML][HTML] Secondary cardiovascular prevention after acute coronary syndrome: emerging risk factors and novel therapeutic targets

A Silverio, FP Cancro, L Esposito, M Bellino… - Journal of Clinical …, 2023 - mdpi.com
The control of cardiovascular risk factors, the promotion of a healthy lifestyle, and
antithrombotic therapy are the cornerstones of secondary prevention after acute coronary …

[HTML][HTML] Colchicine in athero-thrombosis: molecular mechanisms and clinical evidence

G Cimmino, FS Loffredo, G De Rosa… - International Journal of …, 2023 - mdpi.com
Several lines of evidence have clearly indicated that inflammation plays a pivotal role in the
development of atherosclerosis and of its thrombotic complications such as acute coronary …

[HTML][HTML] Safety and efficacy of bempedoic acid: A systematic review and meta-analysis of randomised controlled trials

O De Filippo, F D'Ascenzo, M Iannaccone… - Cardiovascular …, 2023 - Springer
Abstract Background and aims Bempedoic Acid (BA) is a novel Lipid-Lowering Therapy
(LLT). We performed a systematic review and meta-analysis to assess the efficacy and …

Colchicine–new horizons for an ancient drug. Review based on the highest hierarchy of evidence

A Schattner - European Journal of Internal Medicine, 2022 - Elsevier
Colchicine is an old, inexpensive, and relatively safe anti-inflammatory drug traditionally
used in gout and over the last 50 years in familial Mediterranean fever. A search of all high …

Safety and efficacy of colchicine for the prevention of post-operative atrial fibrillation in patients undergoing cardiac surgery: a meta-analysis of randomized controlled …

S Agarwal, CW Beard, J Khosla, S Clifton… - Europace, 2023 - academic.oup.com
Abstract Background and Aims Colchicine is an anti-inflammatory drug that may prevent
post-operative atrial fibrillation (POAF). The effect of this drug has been inconsistently shown …

[HTML][HTML] Colchicine and coronary heart disease risks: A meta-analysis of randomized controlled clinical trials

Z Ma, J Chen, K Jin, X Chen - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Background Several trials have considered the safety and clinical benefits of colchicine as a
treatment option for secondary prevention in patients with coronary atherosclerotic heart …

[PDF][PDF] Colchicine for cardiovascular therapy: A drug interaction perspective and a safety meta-analysis

S Şen, E Karahan, C Büyükulaş… - Anatolian Journal of …, 2021 - jag.journalagent.com
Objective: In this study, we aimed to overview the drug interactions between colchicine and
cardiovascular drugs and performed a metaanalysis to evaluate the safety profile of …

[HTML][HTML] Study on the mechanism of action of colchicine in the treatment of coronary artery disease based on network pharmacology and molecular docking …

Y Yu, M Zhou, X Long, S Yin, G Hu, X Yang… - Frontiers in …, 2023 - frontiersin.org
Objective: This is the first study to explore the mechanism of colchicine in treating coronary
artery disease using network pharmacology and molecular docking technology, aiming to …