Simple Summary Hypoxia is defined as the inadequate supply of oxygen in tissues. Regions
of acute and chronic hypoxia are a universal feature of the tumor microenvironment and a …

Epilepsy is a group of chronic neurological disorders characterized by recurrent,
spontaneous, and unpredictable seizures. It is one of the most common neurological …

It is well documented that hypoxia activates the hypoxia-inducible factor 1-alpha
(HIF1α)/vascular endothelial growth factor A (VEGFA) axis to promote angiogenesis in …

Chemokines mediate monocyte adhesion to dysfunctional endothelial cells (ECs) and
promote arterial inflammation during atherosclerosis. Hypoxia-inducible factor (HIF)-1α is …

Background Cancer cells possess a common metabolic phenotype, rewiring their metabolic
pathways from mitochondrial oxidative phosphorylation to aerobic glycolysis and anabolic …

Infants who are exclusively breastfed in the first six months of age receive adequate
nutrients, achieving optimal immune protection and growth. In addition to the known …

The pathogenesis of chronic kidney disease (CKD) is complex and apparently multifactorial.
Hypoxia or decrease in oxygen supply in kidney tissues has been implicated in CKD …

Every cell in the body requires oxygen for its functioning, in virtually every animal, and a
tightly regulated system that balances oxygen supply and demand is therefore fundamental …

Cells respond to hypoxia by shifting cellular processes from general housekeeping functions
to activating specialized hypoxia-response pathways. Oxygen plays an important role in …

Simple Summary The complex signaling networks that different cancers utilize for cell
survival remain poorly understood. A major problem is the complexity of the tumor …