The nitric oxide (NO) secreted by vascular endothelium is required for the maintenance of
cardiovascular homeostasis. Diminished release of NO generated by endothelial NO …

Altered cellular metabolism is a fundamental adaptation of cancer during rapid proliferation
as a result of growth factor overstimulation. We review different pathways involving …

Hypoxia is a classic characteristic of the tumor microenvironment with a significant impact on
cancer progression and therapeutic response. Hypoxia-inducible factor-1 alpha (HIF-1α) …

Hypoxia-inducible factors (HIF) are heterodimeric transcription factors that allow cells to
adapt and survive during hypoxia. Regulation of HIF1A and HIF2A mRNA is well …

Placental and fetal hypoxia caused by perinatal hypoxic-ischemic events are major causes
of stillbirth, neonatal morbidity, and long-term neurological sequelae among surviving …

Tissue engineering aims to offer large-scale replacement of damaged organs using implants
with the combination of cells, growth factors and scaffolds. However, the intra/peri‑implant …

Extensive and in-depth investigations of high-altitude adaptation have been carried out at
the level of morphology, anatomy, physiology and genomics, but few investigations focused …

Simple Summary In this review, we discuss how miRNAs play a critical role in the regulation
of mRNA stability and translation, how determining the direct targets of miRNAs in complex …

When confronted with poor oxygenation, cells adapt by activating survival signaling
pathways, including the oxygen-sensitive transcriptional regulators called hypoxia-inducible …

Sepsis is a highly heterogeneous syndrome that is caused by an imbalanced host response
to infection. Despite huge investments, sepsis remains a contemporary threat with significant …