The timing of life on Earth is remarkable: between individuals of the same species, a highly
similar temporal pattern is observed, with shared periods of activity and inactivity each day …

Gastric cancer (GC) is one of the most common cancers in the world and a significant threat
to the health of patients, especially those from China and Japan. The prognosis for patients …

The miR-200 family, consisting of miR-200a/b/c, miR-141, and miR-429, is well known to
inhibit epithelial-to-mesenchymal transition (EMT) in cancer invasion and metastasis …

MicroRNAs (miRNAs) are 17-22 nucleotide, non-coding, single stranded RNA molecules
that play a key role in post-transcriptional gene regulation. Hypoxia is a reduction in the …

Understanding the cellular pathways that regulate endothelial nitric oxide (eNOS, NOS3)
expression and consequently nitric oxide (NO) bioavailability during hypoxia is a necessary …

Background Hypoxic conditions induce the expression of hypoxia-inducible factors (HIFs)
that allow cells to adapt to the changing conditions and alter the expression of a number of …

Since the beginning of the discovery of microRNAs (miRs), these molecules have attracted
highly progressive attention due to their powerful regulatory roles in a broad spectrum of …

Background Hypoxia naturally happens in embryogenesis and thus serves as an important
environmental factor affecting embryo development. Hif-1α, an essential hypoxia response …

The role of microRNAs in controlling angiogenesis is recognized as a promising therapeutic
target in both cancer and cardiovascular disorders. However, understanding a miRNA's …

Hypoxia inducible factor-1α facilitates cellular adaptation to hypoxic conditions. Hence its
tight regulation is crucial in hypoxia related diseases such as cerebral ischemia. Changes in …