The pulmonary endothelium is dysfunctional in chronic obstructive pulmonary disease
(COPD), a known risk factor for lung cancer. The pulmonary endothelium is altered in …

Osteogenic differentiation is regulated through multiple signaling networks that may include
responses to hypoxia. Antioxidant ferulic acid (FA) can promote hypoxia signaling by …

Abstract Hypoxia-inducible factor-1 alpha (HIF-1α) is over-expressed in many cancers
including pancreatic ductal adenocarcinoma (PDAC) and correlated with poor prognosis …

MicroRNAs (miRs) are small regulatory RNA transcripts capable of post-transcriptional
silencing of mRNA messages by entering a cellular bimolecular apparatus called RNA …

Highlights•HIF-1α is actively involved in tumorigenesis whereas HIF-2α is predominant in
metastasis and chemoresistance.•HIF-1α is active under severe hypoxic condition whereas …

Hypoxia-Inducible Factors (HIFs) play essential roles in the physiological response to low
oxygen in all multicellular organisms, while their deregulation is associated with human …

The clinical manifestations of pterygium are characterized by rapid growth and postoperative
recurrences. We had previously proposed that hypoxia-inducible factor (HIF)-1α recruits …

While the role of hypoxia and the induction of the hypoxia inducible factors (HIFs) and the
unfolded protein response (UPR) pathways in the cancer microenvironment are well …

Hypoxia-inducible factors (HIFs) play a crucial role in cellular responses to low oxygen
levels during myocardial ischemia and reperfusion injury. HIF stabilizers, originally …

The cellular adaptation to hypoxia is regulated by hypoxia inducible factors: HIF-1 and HIF-
2. HIF-1 mediates response to acute hypoxia, whereas HIF-2 allows adaptation to chronic …