HIF-1α/Ascl2/miR-200b regulatory feedback circuit modulated the epithelial-mesenchymal transition (EMT) in colorectal cancer cells

Y Shang, H Chen, J Ye, X Wei, S Liu, R Wang - Experimental cell research, 2017 - Elsevier
We have reported that Achaete scute-like 2 (Ascl2) transcriptionally repressed miR-200
family members and affected the epithelial-mesenchymal transition (EMT)-mesenchymal …

miRNA networks modulate human endothelial cell adaptation to cyclic hypoxia

K Kochan-Jamrozy, J Króliczewski, A Moszyńska… - Cellular signalling, 2019 - Elsevier
Solid tumor microenvironments are often subjected to various levels of hypoxia. Although
regulation of gene expression has been examined extensively, most studies have focused …

miR‐200a/b/‐429 downregulation is a candidate biomarker of tumor radioresistance and independent of hypoxia in locally advanced cervical cancer

A Nilsen, T Hillestad, VE Skingen… - Molecular …, 2022 - Wiley Online Library
Many patients with locally advanced cervical cancer experience recurrence within the
radiation field after chemoradiotherapy. Biomarkers of tumor radioresistance are required to …

Novel cancer treatment paradigm targeting hypoxia-induced factor in conjunction with current therapies to overcome resistance

TW Kao, GH Bai, TL Wang, IM Shih… - Journal of Experimental …, 2023 - Springer
Chemotherapy, radiotherapy, targeted therapy, and immunotherapy are established cancer
treatment modalities that are widely used due to their demonstrated efficacy against tumors …

Hypoxia-mediated chemotaxis and residence of macrophage in decidua by secreting VEGFA and CCL2 during normal pregnancy

XY Qin, HH Shen, XY Zhang, X Zhang, F Xie… - …, 2023 - rep.bioscientifica.com
In brief Hypoxia is vital for the establishment of the maternal–fetal interface during early
pregnancy. This study shows that decidual macrophages (dMφ) could be recruited and …

Hypoxia and connectivity in the developing vertebrate nervous system

JL Bonkowsky, JH Son - Disease Models & Mechanisms, 2018 - journals.biologists.com
The developing nervous system depends upon precise regulation of oxygen levels.
Hypoxia, the condition of low oxygen concentration, can interrupt developmental sequences …

[HTML][HTML] Salidroside protects hypoxia-induced injury by up-regulation of miR-210 in rat neural stem cells

R Yan, H Xu, X Fu - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Neonatal brain hypoxia is a disease that affects the nervous system in children. Salidroside
is a compound that has an anti-hypoxic effect, but the mechanism of salidroside in neonatal …

[HTML][HTML] Hypoxia-induced MicroRNA-429 promotes differentiation of MC3T3-E1 osteoblastic cells by mediating ZFPM2 expression

J Huang, J Peng, G Cao, S Lu, L Liu, Z Li… - Cellular Physiology and …, 2016 - karger.com
Background/Aims: Hypoxia has been reported to regulate osteoblastic differentiation of bone
cells and cartilage development. However, information concerning the molecular …

MicroRNA‑30a increases the chemosensitivity of U251 glioblastoma cells to temozolomide by directly targeting beclin 1 and inhibiting autophagy

J Xu, H Huang, R Peng, X Ding… - Experimental and …, 2018 - spandidos-publications.com
Temozolomide (TMZ) is one of the most commonly used drugs for the clinical treatment of
glioblastomas. However, it has been reported that treatment with TMZ can induce …

LncRNA MIAT facilitated BM-MSCs differentiation into endothelial cells and restored erectile dysfunction via targeting miR-200a in a rat model of erectile dysfunction

XG Ding, JJ Yang, S Li, H Zheng, CH Gu, ZK Jia… - European Journal of …, 2018 - Elsevier
Background Bone-marrow derived mesenchymal stem cells (BM-MSCs) implantation
effectively restored rats' erectile dysfunction (ED). Long noncoding RNA (LncRNA) …