Background Cardiogenic shock (CS) alters whole body metabolism and circulating
biomarkers serve as prognostic markers in CS patients. Percutaneous ventricular assist …

Hypoxia causes changes in transcription of the genes that contribute to adaptation of the
cells to low levels of oxygen. The main mechanism regulating cellular response to hypoxia is …

Endothelial progenitor cells (EPCs) participate in angiogenesis by differentiating into
endothelial cells (ECs) and may be developed to treat ischemia/reperfusion injury …

New Findings What is the topic of this review? This review highlights the transcriptional
consequences for decreased cellular O2 levels (hypoxia) and increased cellular CO2 levels …

Higher levels of circulatory nitric oxide (NO) and NO metabolites reportedly facilitate high
altitude acclimatization. But the underlying factors and molecular pathways promoting NO …

The blood− spinal cord barrier (BSCB) is an effective, tightly-connected tissue that reduces
secondary spinal cord injury (SCI) by decreasing blood cell infiltration, inflammation, and …

Objective: The objective of the present work was to study the role of Cxcl1 in cerebral
ischemia–reperfusion (I/R) injury and to in-depth explore its pathogenesis. Methods: The …

Abstract Hypoxia-inducible factor-1α (HIF-1α) is a key transcription factor for regulating
oxygen-dependent homeostasis. Here, we characterized HIF-1α in Pacific abalone (Haliotis …

Eprosartan (EPRO), an angiotensin receptor type‐1 (AT‐1) blocker, exhibited
neuroprotective activities in ischemic stroke resulting from focal cerebral ischemia in rats …

Cisplatin is a widely used, highly effective chemotherapy drug that has a critical nephrotoxic
side effect associated with acute kidney injury. Hypoxia pre-treatment is one of the methods …