[HTML][HTML] The therapeutic effects of saikosaponins on depression through the modulation of neuroplasticity: From molecular mechanisms to potential clinical …

S Chen, K Wang, H Wang, Y Gao, K Nie, X Jiang… - Pharmacological …, 2024 - Elsevier
Depression is a major global health issue that urgently requires innovative and precise
treatment options. In this context, saikosaponin has emerged as a promising candidate …

[HTML][HTML] The function of microbial enzymes in breaking down soil contaminated with pesticides: a review

XK Chia, T Hadibarata, RA Kristanti… - Bioprocess and …, 2024 - Springer
The use of pesticides and the subsequent accumulation of residues in the soil has become a
worldwide problem. Organochlorine (OC) pesticides have spread widely in the environment …

[HTML][HTML] Human forebrain organoid-based multi-omics analyses of PCCB as a schizophrenia associated gene linked to GABAergic pathways

W Zhang, M Zhang, Z Xu, H Yan, H Wang… - Nature …, 2023 - nature.com
Identifying genes whose expression is associated with schizophrenia (SCZ) risk by
transcriptome-wide association studies (TWAS) facilitates downstream experimental studies …

[HTML][HTML] Effects of rumen-protective γ-aminobutyric acid additive on lactation performance and serum biochemistry in heat-stressed cows

Y Su, Z Cheng, W Liu, T Wu, W Wang… - Frontiers in Veterinary …, 2023 - frontiersin.org
In the context of global warming, heat stress has become one of the major stress factors
limiting dairy cattle production. Although many methods have been explored to help cows …

Neurotoxicity and brain metabolic dysfunction induced by long-term food-derived arsenic exposure

Z Huang, L Guo, J Huang, X Chen, J Sun, Y Ye… - Food Bioscience, 2024 - Elsevier
Rice consumption are a major cause of long-term exposure to arsenic. However, the exact
mechanism of the neurotoxic action caused by arsenic exposure remain elusive. The …

[HTML][HTML] Biotransformed bear bile powder alleviates diet-induced nonalcoholic fatty liver disease in mice by regulating the gut microbiota and reversing lipid …

S Jiang, X Wei, H Wang, Y Zhou, L Chen… - Arabian Journal of …, 2024 - Elsevier
Background The pathogenesis of metabolic syndrome was strongly associated with
compromised metabolism homeostasis and gut microbiota imbalance. NAFLD is a …

[HTML][HTML] Persistent gene expression and DNA methylation alterations linked to carcinogenic effects of dichloroacetic acid

G Carswell, J Chamberlin, BD Bennett… - Frontiers in …, 2024 - ncbi.nlm.nih.gov
Background Mechanistic understanding of transient exposures that lead to adverse health
outcomes will enhance our ability to recognize biological signatures of disease. Here, we …

Identification of Ion Channel-Related Genes as Diagnostic Markers and Potential Therapeutic Targets for Osteoarthritis Through Bioinformatics and Machine Learning …

L Yongming, X Yizhe, Q Zhikai, W Yupeng, W Xiang… - Biomarkers, 2024 - Taylor & Francis
Background Osteoarthritis (OA) is a debilitating joint disorder characterized by the
progressive degeneration of articular cartilage. Although the role of ion channels in OA …

[HTML][HTML] Effects of magnetic field pretreatment and chloride salt stress on physio-biochemical changes and γ-aminobutyric acid accumulation in germinated brown rice

Y Zhu, S Tan, C Xie, D Li, P Wang… - Food Materials …, 2024 - maxapress.com
Germinated brown rice is a staple food with high nutritional value and market prospects.
Gamma-Aminobutyric Acid (GABA), abundantly present in germinated brown rice, has …

GABA production induced by imipridones is a targetable and imageable metabolic alteration in diffuse midline gliomas

G Batsios, S Udutha, C Taglang, AM Gillespie, B Lau… - bioRxiv, 2024 - biorxiv.org
Diffuse midline gliomas (DMGs) are lethal primary brain tumors in children. The imipridones
ONC201 and ONC206 induce mitochondrial dysfunction and have emerged as promising …