[HTML][HTML] The therapeutic effects of saikosaponins on depression through the modulation of neuroplasticity: From molecular mechanisms to potential clinical …
S Chen, K Wang, H Wang, Y Gao, K Nie, X Jiang… - Pharmacological …, 2024 - Elsevier
Depression is a major global health issue that urgently requires innovative and precise
treatment options. In this context, saikosaponin has emerged as a promising candidate …
treatment options. In this context, saikosaponin has emerged as a promising candidate …
[HTML][HTML] The function of microbial enzymes in breaking down soil contaminated with pesticides: a review
XK Chia, T Hadibarata, RA Kristanti… - Bioprocess and …, 2024 - Springer
The use of pesticides and the subsequent accumulation of residues in the soil has become a
worldwide problem. Organochlorine (OC) pesticides have spread widely in the environment …
worldwide problem. Organochlorine (OC) pesticides have spread widely in the environment …
[HTML][HTML] Human forebrain organoid-based multi-omics analyses of PCCB as a schizophrenia associated gene linked to GABAergic pathways
W Zhang, M Zhang, Z Xu, H Yan, H Wang… - Nature …, 2023 - nature.com
Identifying genes whose expression is associated with schizophrenia (SCZ) risk by
transcriptome-wide association studies (TWAS) facilitates downstream experimental studies …
transcriptome-wide association studies (TWAS) facilitates downstream experimental studies …
[HTML][HTML] Effects of rumen-protective γ-aminobutyric acid additive on lactation performance and serum biochemistry in heat-stressed cows
Y Su, Z Cheng, W Liu, T Wu, W Wang… - Frontiers in Veterinary …, 2023 - frontiersin.org
In the context of global warming, heat stress has become one of the major stress factors
limiting dairy cattle production. Although many methods have been explored to help cows …
limiting dairy cattle production. Although many methods have been explored to help cows …
Neurotoxicity and brain metabolic dysfunction induced by long-term food-derived arsenic exposure
Z Huang, L Guo, J Huang, X Chen, J Sun, Y Ye… - Food Bioscience, 2024 - Elsevier
Rice consumption are a major cause of long-term exposure to arsenic. However, the exact
mechanism of the neurotoxic action caused by arsenic exposure remain elusive. The …
mechanism of the neurotoxic action caused by arsenic exposure remain elusive. The …
[HTML][HTML] Biotransformed bear bile powder alleviates diet-induced nonalcoholic fatty liver disease in mice by regulating the gut microbiota and reversing lipid …
S Jiang, X Wei, H Wang, Y Zhou, L Chen… - Arabian Journal of …, 2024 - Elsevier
Background The pathogenesis of metabolic syndrome was strongly associated with
compromised metabolism homeostasis and gut microbiota imbalance. NAFLD is a …
compromised metabolism homeostasis and gut microbiota imbalance. NAFLD is a …
[HTML][HTML] Persistent gene expression and DNA methylation alterations linked to carcinogenic effects of dichloroacetic acid
G Carswell, J Chamberlin, BD Bennett… - Frontiers in …, 2024 - ncbi.nlm.nih.gov
Background Mechanistic understanding of transient exposures that lead to adverse health
outcomes will enhance our ability to recognize biological signatures of disease. Here, we …
outcomes will enhance our ability to recognize biological signatures of disease. Here, we …
Identification of Ion Channel-Related Genes as Diagnostic Markers and Potential Therapeutic Targets for Osteoarthritis Through Bioinformatics and Machine Learning …
L Yongming, X Yizhe, Q Zhikai, W Yupeng, W Xiang… - Biomarkers, 2024 - Taylor & Francis
Background Osteoarthritis (OA) is a debilitating joint disorder characterized by the
progressive degeneration of articular cartilage. Although the role of ion channels in OA …
progressive degeneration of articular cartilage. Although the role of ion channels in OA …
[HTML][HTML] Effects of magnetic field pretreatment and chloride salt stress on physio-biochemical changes and γ-aminobutyric acid accumulation in germinated brown rice
Y Zhu, S Tan, C Xie, D Li, P Wang… - Food Materials …, 2024 - maxapress.com
Germinated brown rice is a staple food with high nutritional value and market prospects.
Gamma-Aminobutyric Acid (GABA), abundantly present in germinated brown rice, has …
Gamma-Aminobutyric Acid (GABA), abundantly present in germinated brown rice, has …
GABA production induced by imipridones is a targetable and imageable metabolic alteration in diffuse midline gliomas
Diffuse midline gliomas (DMGs) are lethal primary brain tumors in children. The imipridones
ONC201 and ONC206 induce mitochondrial dysfunction and have emerged as promising …
ONC201 and ONC206 induce mitochondrial dysfunction and have emerged as promising …