RNA combined with nanoformulation to advance therapeutic technologies

ES Lima, D Dos Santos, AL Souza, ME Macedo… - Pharmaceuticals, 2023 - mdpi.com
Nucleic acid-based therapies have the potential to address numerous diseases that pose
significant challenges to more traditional methods. RNA-based therapies have emerged as …

[HTML][HTML] Cannabidiol nanoemulsion for eye treatment–Anti-inflammatory, wound healing activity and its bioavailability using in vitro human corneal substitute

O Strnad, J Šuman, T Veverková, A Sukupová… - International Journal of …, 2023 - Elsevier
Cannabidiol (CBD) is the non-psychoactive component of the plant Cannabis sativa (L.) that
has great anti-inflammatory benefits and wound healing effects. However, its high …

Formulation and in Vitro-Ex vivo evaluation of cannabidiol and Cannabidiol-Valine-Hemisuccinate loaded Lipid-Based nanoformulations for ocular applications

AAA Youssef, MH Abdelrahman, MM Geweda… - International Journal of …, 2024 - Elsevier
The goal of this investigation is to develop stable ophthalmic nanoformulations containing
cannabidiol (CBD) and its analog cannabidiol-valine-hemisuccinate (CBD-VHS) for …

Prospective affirmative therapeutics of cannabidiol oil mitigates doxorubicin-induced abnormalities in kidney function, inflammation, and renal tissue changes

NA Soliman, SIE Dahmy, AA Shalaby… - Naunyn-Schmiedeberg's …, 2024 - Springer
Nephropathy is the decline in kidney function. A promising treatment for numerous types of
illness is using natural materials as natural chemical compounds. The inquiry was …

Development and optimization of a one step process for the production and sterilization of liposomes using supercritical CO2

N Penoy, KL Delma, N Homkar, AK Sakira… - International Journal of …, 2024 - Elsevier
Liposomes are very interesting drug delivery systems for pharmaceutical and therapeutic
purposes. However, liposome sterilization as well as their industrial manufacturing remain …

Protective Effects of Cannabidiol (CBD) against Qxidative Stress, but Not Excitotoxic-Related Neuronal Cell Damage—An In Vitro Study

D Jantas, M Leśkiewicz, M Regulska, M Procner… - Biomolecules, 2024 - mdpi.com
Cannabidiol (CBD) appears to possess some neuroprotective properties, but experimental
data are still inconsistent. Therefore, this in vitro study aimed to compare the effects of CBD …

Cannabidiol-Loaded Solid Lipid Nanoparticles Ameliorate the Inhibition of Proinflammatory Cytokines and Free Radicals in an In Vitro Inflammation-Induced Cell …

KP Alcantara, JWT Malabanan, N Nalinratana… - International Journal of …, 2024 - mdpi.com
Cannabidiol (CBD) is a non-psychoactive compound derived from Cannabis sativa. It has
demonstrated promising effects in combating inflammation and holds potential as a …

Assessing the Safety and Therapeutic Efficacy of Cannabidiol Lipid Nanoparticles in Alleviating Metabolic and Memory Impairments and Hippocampal …

S Lapmanee, S Bhubhanil, P Wongchitrat… - Pharmaceutics, 2024 - mdpi.com
Diabetic Parkinson's disease (DP) is a progressive neurodegenerative disease with
metabolic syndrome that is increasing worldwide. Emerging research suggests that …

Pharmacokinetics of Two Nanoemulsion Formulations of Δ8-Tetrahydrocannabinol in Rats

M Tagen, LE Klumpers, A Peshkovsky - AAPS PharmSciTech, 2023 - Springer
The use of Δ8-tetrahydrocannabinol (Δ8-THC) has increased in recent years. Given that the
oral absorption of cannabinoids in oil formulations is typically slow and variable …

Experimental acute anti-inflammatory activity of preparations with complexed cannabidiol in carriers

DR Grijó, EMT Rocha, VC Almeida… - Brazilian Journal of …, 2023 - SciELO Brasil
Cannabidiol (CBD) is a bioactive compound with promising anti-inflammatory results but has
low aqueous solubility. Complexation of drugs with this characteristic in carriers is an …