How neuroinflammation contributes to neurodegeneration
RM Ransohoff - Science, 2016 - science.org
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and frontotemporal lobar dementia are among the most …
amyotrophic lateral sclerosis, and frontotemporal lobar dementia are among the most …
Microglial activation in traumatic brain injury
CK Donat, G Scott, SM Gentleman… - Frontiers in aging …, 2017 - frontiersin.org
Microglia have a variety of functions in the brain, including synaptic pruning, CNS repair and
mediating the immune response against peripheral infection. Microglia rapidly become …
mediating the immune response against peripheral infection. Microglia rapidly become …
Microglia in multiple sclerosis: friend or foe?
BL Guerrero, NL Sicotte - Frontiers in immunology, 2020 - frontiersin.org
Microglia originate from myeloid progenitors in the embryonic yolk sac and play an integral
role in central nervous system (CNS) development, immune surveillance and repair. The …
role in central nervous system (CNS) development, immune surveillance and repair. The …
Early and protective microglial activation in Alzheimer's disease: a prospective study using 18 F-DPA-714 PET imaging
L Hamelin, J Lagarde, G Dorothée, C Leroy, M Labit… - Brain, 2016 - academic.oup.com
While emerging evidence suggests that neuroinflammation plays a crucial role in
Alzheimer's disease, the impact of the microglia response in Alzheimer's disease remains a …
Alzheimer's disease, the impact of the microglia response in Alzheimer's disease remains a …
Cellular sources of TSPO expression in healthy and diseased brain
E Nutma, K Ceyzériat, S Amor, S Tsartsalis… - European journal of …, 2021 - Springer
The 18 kDa translocator protein (TSPO) is a highly conserved protein located in the outer
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …
A molecular imaging primer: modalities, imaging agents, and applications
ML James, SS Gambhir - Physiological reviews, 2012 - journals.physiology.org
Molecular imaging is revolutionizing the way we study the inner workings of the human
body, diagnose diseases, approach drug design, and assess therapies. The field as a whole …
body, diagnose diseases, approach drug design, and assess therapies. The field as a whole …
Evidence for brain glial activation in chronic pain patients
Although substantial evidence has established that microglia and astrocytes play a key role
in the establishment and maintenance of persistent pain in animal models, the role of glial …
in the establishment and maintenance of persistent pain in animal models, the role of glial …
Roles of microglia in brain development, tissue maintenance and repair
The emerging roles of microglia are currently being investigated in the healthy and diseased
brain with a growing interest in their diverse functions. In recent years, it has been …
brain with a growing interest in their diverse functions. In recent years, it has been …
Neuroimaging biomarkers for Alzheimer's disease
F Márquez, MA Yassa - Molecular neurodegeneration, 2019 - Springer
Currently, over five million Americans suffer with Alzheimer's disease (AD). In the absence of
a cure, this number could increase to 13.8 million by 2050. A critical goal of biomedical …
a cure, this number could increase to 13.8 million by 2050. A critical goal of biomedical …
An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28
[11C] PBR28 binds the 18-kDa Translocator Protein (TSPO) and is used in positron
emission tomography (PET) to detect microglial activation. However, quantitative …
emission tomography (PET) to detect microglial activation. However, quantitative …