Single-entity electrochemistry (SEE) describes a recent trend in state-of-the-art
electrochemistry applied to the study of individual “things.” Conceptually, SEE covers …

Much more than ever, nucleic acids are recognized as key building blocks in many of lifeʼs
processes, and the science of studying these molecular wonders at the single-molecule …

Nanopores have recently been used to identify and fingerprint proteins. However, because
proteins, unlike DNA, do not have a uniform charge, the electrophoretic force cannot in …

The precise assembly and engineering of molecular machines capable of handling
biomolecules play crucial roles in most single-molecule methods. In this work we use …

Formation of amyloid-beta (Aβ) oligomer pores in the membrane of neurons has been
proposed to explain neurotoxicity in Alzheimerʼs disease (AD). Here, we present the three …

Single-molecule long-read DNA sequencing with biological nanopores is fast and high-
throughput but suffers reduced accuracy in homonucleotide stretches. We now combine the …

The design of peptides that assemble in membranes to form functional ion channels is
challenging. Specifically, hydrophobic interactions must be designed between the peptides …

Nanopores bear great potential as single-molecule tools for bioanalytical sensing and
sequencing, due to their exceptional sensing capabilities, high-throughput, and low cost …

Cells are divided into compartments and separated from the environment by lipid bilayer
membranes. Essential molecules are transported back and forth across the membranes. We …

Protein nanopores have been used as stochastic sensors for the detection of analytes that
range from small molecules to proteins. In this approach, individual analyte molecules …