Heart failure in type 2 diabetes mellitus: impact of glucose-lowering agents, heart failure therapies, and novel therapeutic strategies

HC Kenny, ED Abel - Circulation research, 2019 - Am Heart Assoc
Patients with diabetes mellitus have> 2× the risk for developing heart failure (HF; HF with
reduced ejection fraction and HF with preserved ejection fraction). Cardiovascular …

Immune pathways in etiology, acute phase, and chronic sequelae of ischemic stroke

M Endres, MA Moro, CH Nolte, C Dames… - Circulation …, 2022 - Am Heart Assoc
Inflammation and immune mechanisms are crucially involved in the pathophysiology of the
development, acute damage cascades, and chronic course after ischemic stroke …

Colchicine in patients with acute coronary syndrome: the Australian COPS randomized clinical trial

DC Tong, S Quinn, A Nasis, C Hiew… - Circulation, 2020 - Am Heart Assoc
Background: Inflammation plays a crucial role in clinical manifestations and complications of
acute coronary syndromes (ACS). Colchicine, a commonly used treatment for gout, has …

[HTML][HTML] Antiinflammatory therapy with canakinumab for atherosclerotic disease

PM Ridker, BM Everett, T Thuren… - New England journal …, 2017 - Mass Medical Soc
Background Experimental and clinical data suggest that reducing inflammation without
affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory …

NLRP3 inflammasome and the IL-1 pathway in atherosclerosis

A Grebe, F Hoss, E Latz - Circulation research, 2018 - Am Heart Assoc
Inflammation is an important driver of atherosclerosis, the underlying pathology of
cardiovascular diseases. Therefore, therapeutic targeting of inflammatory pathways is …

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

JJ Fuster, S MacLauchlan, MA Zuriaga, MN Polackal… - Science, 2017 - science.org
Human aging is associated with an increased frequency of somatic mutations in
hematopoietic cells. Several of these recurrent mutations, including those in the gene …

[HTML][HTML] Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19

A Gupta, MV Madhavan, TJ Poterucha… - Nature …, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) can result in a hyperinflammatory state,
leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic …

Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation

C Yao, T Veleva, L Scott Jr, S Cao, L Li, G Chen… - Circulation, 2018 - Am Heart Assoc
Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …

Clinical update: cardiovascular disease in diabetes mellitus: atherosclerotic cardiovascular disease and heart failure in type 2 diabetes mellitus–mechanisms …

CC Low Wang, CN Hess, WR Hiatt, AB Goldfine - Circulation, 2016 - Am Heart Assoc
Cardiovascular disease remains the principal cause of death and disability among patients
with diabetes mellitus. Diabetes mellitus exacerbates mechanisms underlying …

[HTML][HTML] Natural products from cyanobacteria: Focus on beneficial activities

J Demay, C Bernard, A Reinhardt, B Marie - Marine drugs, 2019 - mdpi.com
Cyanobacteria are photosynthetic microorganisms that colonize diverse environments
worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their …