Heart failure in type 2 diabetes mellitus: impact of glucose-lowering agents, heart failure therapies, and novel therapeutic strategies
HC Kenny, ED Abel - Circulation research, 2019 - Am Heart Assoc
Patients with diabetes mellitus have> 2× the risk for developing heart failure (HF; HF with
reduced ejection fraction and HF with preserved ejection fraction). Cardiovascular …
reduced ejection fraction and HF with preserved ejection fraction). Cardiovascular …
Immune pathways in etiology, acute phase, and chronic sequelae of ischemic stroke
Inflammation and immune mechanisms are crucially involved in the pathophysiology of the
development, acute damage cascades, and chronic course after ischemic stroke …
development, acute damage cascades, and chronic course after ischemic stroke …
Colchicine in patients with acute coronary syndrome: the Australian COPS randomized clinical trial
DC Tong, S Quinn, A Nasis, C Hiew… - Circulation, 2020 - Am Heart Assoc
Background: Inflammation plays a crucial role in clinical manifestations and complications of
acute coronary syndromes (ACS). Colchicine, a commonly used treatment for gout, has …
acute coronary syndromes (ACS). Colchicine, a commonly used treatment for gout, has …
[HTML][HTML] Antiinflammatory therapy with canakinumab for atherosclerotic disease
PM Ridker, BM Everett, T Thuren… - New England journal …, 2017 - Mass Medical Soc
Background Experimental and clinical data suggest that reducing inflammation without
affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory …
affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory …
NLRP3 inflammasome and the IL-1 pathway in atherosclerosis
A Grebe, F Hoss, E Latz - Circulation research, 2018 - Am Heart Assoc
Inflammation is an important driver of atherosclerosis, the underlying pathology of
cardiovascular diseases. Therefore, therapeutic targeting of inflammatory pathways is …
cardiovascular diseases. Therefore, therapeutic targeting of inflammatory pathways is …
Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
Human aging is associated with an increased frequency of somatic mutations in
hematopoietic cells. Several of these recurrent mutations, including those in the gene …
hematopoietic cells. Several of these recurrent mutations, including those in the gene …
[HTML][HTML] Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19
A Gupta, MV Madhavan, TJ Poterucha… - Nature …, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) can result in a hyperinflammatory state,
leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic …
leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic …
Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation
C Yao, T Veleva, L Scott Jr, S Cao, L Li, G Chen… - Circulation, 2018 - Am Heart Assoc
Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …
Clinical update: cardiovascular disease in diabetes mellitus: atherosclerotic cardiovascular disease and heart failure in type 2 diabetes mellitus–mechanisms …
Cardiovascular disease remains the principal cause of death and disability among patients
with diabetes mellitus. Diabetes mellitus exacerbates mechanisms underlying …
with diabetes mellitus. Diabetes mellitus exacerbates mechanisms underlying …
[HTML][HTML] Natural products from cyanobacteria: Focus on beneficial activities
Cyanobacteria are photosynthetic microorganisms that colonize diverse environments
worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their …
worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their …